Systems Biology x Network Biology GOAL: develop a quantitative understanding of the biological function of genetic and biochemical networks INPUT

MIT Biology Department 7.012: Introductory Biology -Fall 2004 Instructors: Professor Eric Lander, Professor Robert A Weinberg Dr Claudette Gardel BigIdear At the molecular level, biology is based on three- dimensional interactions of complementary molecular surfaces Other important concepts

CHAPTER 1 Developmental Anatomy CHAPTER 2 Developmental Genetics CHAPTER 3 Cell-Cell Communication in Development CHAPTER 4 Fertilization CHAPTER 5 Early Development in Selected Invertebrates CHAPTER 6 The Genetics of Axis Specification in Drosophila CHAPTER 7 Amphibians and Fish CHAPTER 8 Birds and Mammals CHAPTER 9 The Emergence of the Ectoderm CHAPTER 10 Neural Crest Cells and Axonal Specificity CHAPTER 11 Paraxial and Intermediate Mesoderm CHAPTER 12 Lateral Plate Mesoderm and the Endoderm CHAPTER 13 Development of the Tetrapod Limb CHAPTER 14 Sex Determination^ CHAPTER 15 Postembryonic Development CHAPTER 16 The Saga of the Germ Line CHAPTER 17 Medical Aspects of Developmental Biology CHAPTER 18 Developmental Plasticity and Symbiosis CHAPTER 19 Developmental Mechanisms of Evolutionary Change

1.1 Biology is the science of life. Properties of Life. Biology is the science that studies living organisms and how they interact with one another and their environment

7.012: Introductory Biology-Fall 2004 Instructors: Professor Eric Lander, Professor Robert A. Weinberg, Dr. Claudette Gardel Big Idea 1: Biology is based on observational and experimental science. 1. We think what we think because we can draw conclusions from the results of controlled experiments. 2. An informative experiment is designed to distinguish between hypotheses

ntroducing… ecture Recitations TR1:00-2:30PM W4:00-5:00PM Alexander van Oudenaarden juan pedraza

A remarkab|efie|d e One of the two leading technologies in structural biolog y Great contributions to biology A special window to the development of modern structural biology and biophysics THNMR YAN

Molecular Biology of the Gene, 5/E---Watson et al. (2004) Part I: Chemistry and genetics Part l: Maintenance of the Genome Part I: Expression of the Genome Part IV: Regulation Part v: Methods

Chapter 3 Techniques in Cell Biology Preparatory observe put forward theoretics Design control tests Refer to knowledge Collect data Explain results Devise conclusion

1. Overview-the many levels of systems biology 2. Experimental methods for measuring protein-protein interactions and their limitations 3. Data sources for information about proteins and their