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武汉大学生命科学学院:《分子生物学》英文版 CHAPTER 6 Molecular Biology of the Gene

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Molecular Biology of the Gene, 5/E---Watson et al. (2004) Part I: Chemistry and genetics Part l: Maintenance of the Genome Part I: Expression of the Genome Part IV: Regulation Part v: Methods
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Welcome each of You to my molecular Biology class @博来字 Wuhan University

Welcome Each of You to My Molecular Biology Class

Molecular Biology of the Gene, 5/E ---Watson et al. ( 2004) Part l: Chemistry and Genetics Part l: Maintenance of the Genome Part l: Expression of the Genome Part IV: Regulation Part v: Methods 3/08/05 Wuhan University

Molecular Biology of the Gene, 5/E --- Watson et al. (2004) Part I: Chemistry and Genetics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods 3/08/05

Part ll: Maintenance of the genome dedicated to the structure of DNA and the processes that propagate, maintain and alter it from one cell generation to the next

Part II: Maintenance of the Genome Dedicated to the structure of DNA and the processes that propagate, maintain and alter it from one cell generation to the next

Maintenance of the Genome Ch 6: The structures of dna and rna Ch 7: Chromosomes chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of DNA Ch 10: Homologous recombination at the molecular level Ch 11: Site-specific recombination and transposition of DNA 3/08/05

Maintenance of the Genome Ch 6: The structures of DNA and RNA Ch 7: Chromosomes, chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of DNA Ch 10: Homologous recombination at the molecular level Ch 11: Site-specific recombination and transposition of DNA 3/08/05

CHAPTER 6 The structures of dNA and rNa How do the structures of dna and rna account for their functions?

CHAPTER 6 The Structures of DNA and RNA How do the structures of DNA and RNA account for their functions?

OUTLINE 1 DNA Structure 2.DNA Topology 3.RNA Structure

OUTLINE 1.DNA Structure 2.DNA Topology 3.RNA Structure

DNA STRUCTURE

DNA STRUCTURE

DNA is composed of polynucleotide chains sssm Structure: twisting around each o other in the form of a double helix

DNA STRUCTURE ( ) 1 DNA is composed of polynucleotide chains Structure: twisting around each other in the form of a double helix

Schematic model Space-filling model hydrogen bond base 12A sugar-phasphate minor (1.2 henbane groove r 5西 najor(2.2 nm) groove A 3° 5 T H o Cin phosphate C andN P 20 A(2 nm) ester chain in bases

Schematic model Space-filling model

Nucleoside nucleotide, the fundamental building block of DNa ● 2-deoxyribose HO: CH base H phosphoric acid phosphoester bond O—P-OcH H nucleotide (damglycosidic bond Copyright o 2004 Pearson Education, Inc, publishing as Benjamin Cummings

Nucleoside & Nucleotide, the fundamental building block of DNA glycosidic bond phosphoester bond

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