Neurodegenerative diseases and ubiquitin-proteasome syster to copyright considerations See Figure chanover, A and Brundin, P. 2003. The ubiquitin proteasome enerative diseases: sometimes the chicken, sometimes the egg
Cystic fibrosis channels. The R-domain has more than one function. In addition to it's inhibitory role in Cystic fibrosis is a hereditary disease that channel gating (when unphosphorylated)the causes certain glands to produce abnormal
PROTACS: CHIMERIC MOLECULES TO TARGET PROTEINS FOR UBIQUITINATION AND (taken from KM Sakamoto, Mol. Genetics and Metabolism 77(2002)44-56) target targettargettarget target target target target target To circumvent the problem of transducing cells at
Reversible ligation of Ubiquitin and Ubls to other proteins. Figure by MIT OCW. After Figure 1 in Hochstrasser M. Evolution and function of ubiquitin-like protein-conjugation systems. Nat Cell Biol. 2000 Aug:
Who might be immuno-compromised or have a weakened immune system? Examples of persons with weakened immune systems include those with AIDS; cancer and transplant patients who are taking certain immunosuppressive drugs; and those with inherited diseases that affect the immune system
Cyanosis---Hints central cyanosis: implies decreased arterial oxygen saturation Peripheral cyanosis: caused by a decreased rate of peripheral blood flow
What is an enzyme? A biological catalyst that promotes and speeds up a chemical reaction without itself being altered in the process. Lowers the activation energies of a substance
Definition Bacteremia: Bacteria invade into blood temporarily with flora <100 CFU/ml in blood XSepticemia or Sepsis: Pathogens (bacteria or fungi) invade into blood, proliferate greatly, and release endotoxin XToxemia:
