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Cystic fibrosis channels. The R-domain has more than one function. In addition to it's inhibitory role in Cystic fibrosis is a hereditary disease that channel gating (when unphosphorylated)the causes certain glands to produce abnormal
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一、分子病的概念 二、异常血红蛋白病及发病机制 三、地中海贫血及发病机制 四、酶蛋白病
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10.1基因突变 10.2原核生物基因的表达与调控 10.3真核生物基因的表达与调控 10.4基因与人类疾病 10.5HV的结构与分子遗传机制
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蠕虫(helminth):肌肉收缩、蠕形运动、多细胞无脊椎动物医学蠕虫:指引起人类疾病的寄生性蠕虫
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Neurodegenerative diseases and ubiquitin-proteasome syster to copyright considerations See Figure chanover, A and Brundin, P. 2003. The ubiquitin proteasome enerative diseases: sometimes the chicken, sometimes the egg
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《实验动物学》课程PPT教学课件(讲稿)第十章 人类疾病动物模型概述
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Reversible ligation of Ubiquitin and Ubls to other proteins. Figure by MIT OCW. After Figure 1 in Hochstrasser M. Evolution and function of ubiquitin-like protein-conjugation systems. Nat Cell Biol. 2000 Aug:
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Rip: REGULATED INTRAHENBRANE PROTEOLYSis .Site. spacifie membrae. prote2ses Substratey achivated by protcolytc procassing .. SREBP TF controlling rol metabohis IRE1 Unfolded protein response Notch APP \RoP*: REGULATED. UBiQUiTIN/PROTEASOME DEPENDENT PROCESSING\ type ERAD (ER zciakd dxgradatin) process involving proltoly'c procassing:
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正逆转录病毒亚科 (Orthoretrovirinae) Retroviridae 泡沫逆转录病毒亚科 (Spumavirinae) 未发现与人类疾病有关 慢病毒属 Lentivirus: 人免疫缺陷病 毒(HIV-1,2) 丁型逆转录病毒属 Deltaretrovirus:人 嗜T淋巴细胞病毒I型 (HTLV-1)
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How p53 and Rb pathway function may be disrupted in cancer cells Components of the pathway which are found altered in human cancers are shown in red on the diagram above p53 and Rb themselves may be inactivated by gene mutation (loss of both copies or also as in familial retinoblastoma and Li-Fraumeni syndrome where there are inherited mutations in one copy of Rb or p53 gene respectively. Alternatively
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