Introductory slides for Session 3 ER cytosol c48 ufdA 14 (Dub: Deusiquitr acce entyme or 地, chain Ub Ct hydros) 955ab U chaperone)) QC S pReTEASCRE proteolysis ge5 +frokolys's ERAD ER A550 CiATED DE GRADATION
Introductory slides for Session 3
Rip":REGULATED I BRANE PRoTeoLysis 哪 site.specific membrane. locpUaed rote bstrate acided by pro g. SREBP +7F controlling sk rol metabolim Note APP RuP":REGULATEDUBiGUITiN/PROTEASOME DEPENDENT PRoCESSING". type op ERAD (ER 2ssociakd degradation) Proues involving proktolyt'c processin △ a fatty acid desahorme→ biosynthesis unszhurzled ②LE4 Essenti R PATHWAy FOR 3 SURVIVAL mediated ub qilianshan RITcownekzmTIZLILrn (biosynthesis end opml funcity ep Retrotransloartien PATTY Aiby vbc dde 48/u{d TRANSRIPTION Npl4 \265 FACTORS ACT YATION PROTE ASUME
CDs I(. cDI.)M) inflammatory The MHC d:ss工 and class antibody Miclas.I re ponses ntrecellubr extracellular CD4 is the major cello receptor for HIv-1 E◇ F-TrCP is a Fbox protein ert of a Scf es g It doesnt normally interact B-Trcp B-catenin Ubiquitin chain : pu mediates degradation of CD4 and Cont r butes to the T decrease in the expression of mayor histocompability Compler helene Mc) chss I molecules a抛e surface f HIv.I induced cells
