蛋白质组研究的核心是系统识别一个细 胞或组织中表达的每一个蛋白质,以及确定 每个蛋白质的突出特征

Branch of discovery science focusing on proteins In 1994 defined as the complete set of proteins that is expressed and modified following expression by the entire genome in the lifetime of a cell. If we look at an organism it means that we are looking at the proteome of 3 trillion of cells and -1000

1.Definitions: topoisomerase, ribozyme, double helix, DNA denaturation, Tm, linking number, pseudoknot. 2.What are the structural differences between DNA and RNA? How the structural properties of DNA and RNA determine their distinct biological functions

Gene,5/e--- Watson et al.(2004) Part: Chemistry and Genetics Part ll: Maintenance of the Genome Part Ill: Expression of the Genome Part IV: Regulation Part V: Methods

Similarity of regulation between eukaryotes and prokaryote 1. Principles are the same: signals, activators and repressors, recruitment and allostery, cooperative binding 2. Expression of a gene can be regulated at the similar steps, and the initiation of transcription is the most pervasively regulated step

Part III: Expression of the Genome Ch 12: Mechanisms of Transcription Ch 13: RNA Splicing Ch 14: Trans lation Ch 15: The Genetic Code

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