第一节 概述 第二节 药物代谢酶和代谢部位 第三节 药物代谢反应的类型 第四节 影响药物代谢的因素 第五节 药物代谢和制剂设计

第二节 影响药物吸收的因素 第三节 口服药物吸收与制剂设计 第四节 口服药物吸收的

第一节 概述 第二节 影响分布的因素 一、体内循环与血管透过性对分布的影响 二、药物血浆蛋白结合力对分布的影响 三、药物理化性质对药物分布的影响 四、药物与组织亲和力的影响 五、药物相互作用对分布的影响 第三节 淋巴系统转运 第四节 脑内分布 第五节 血细胞内分布 第六节 胎儿内分布 第七节 脂肪组织分布 第八节 药物的体内分布与制剂设计

Section one: Site-specific drug delivery Chapter one Site-specific drug delivery using liposomes as carriers.3 Chapter two Site-specific drug delivery utilizing monoclonal antibodies .35 Section two: Polymers, implantable drug delivery Chapter three Role of polymers in drug delivery .63 Chapter four Implants in drug delivery. 115 Section three: Oral drug delivery Chapter five Oral drug delivery .149 Section four: Transdermal, intranasal, ocular, and miscellaneous drug delivery Chapter six Transdermal drug delivery .207 Chapter seven Intranasal and ocular drug delivery .249 Chapter eight Miscellaneous forms of drug delivery .289

I. Ointments II. Compendial requirements for ointments III. Creams IV. Gels V. Miscellaneous semisolid preparations: pastes and plasters VI. Features and use of dermatologic preparations VII. Features and use of ophthalmic ointments and gels VIII. Features and use of nasal ointments and gels IX. Features and use of rectal preparations X. Features and use of vaginal preparations

I. The rationale for extended-release pharmaceuticals II. Terminology III. Extended-release oral dosage forms IV. Delayed-release oral dosage forms V. USP requirements and FDA Guidance for modified-release dosage forms VI. Clinical considerations in the use of oral modified-release dosage form VII. Packaging and storing modified-release tablets and capsules

介绍制剂生产中的灭菌方法 无菌操作法 衡量灭菌可靠性的参数 洁净室的设计与空气净化技术 无菌检查法

胶囊剂（Capsules）系指原料药物与适宜辅料充填于空心胶囊或密封于软质囊材中制成的固体制剂。丸剂（pills）系指原料药物与适宜的辅料制成的球形或类球形固体制剂

• Introduction • The characteristics of the biotech products • Techniques used to produce biotechnologic products • The pharmaceutical concerns of biotech drug • Products of Biotechnology • The future of the biotech products

❖什么是中药药代动力学 ❖中药药代动力学的发展 ❖目前研究的内容 ❖研究的意义 ❖主要研究方法 ❖限制因素 ❖对策及展望