An introduction of gene function 1, Storing Information 2、 Replication 3、 Mutation

生物学(Biology)是研究生物体的生命现象和 生命活动规律的科学,即:研究自然界所有生物的 起源、演化、生长发育、遗传变异等生命活动的规 律和生命现象的本质,以及各种生物之间、生物与 环境之间的相互联系。生物学又称生命科学(Life Science),它是自然科学的基础学科之一。广义的 生命科学还包括生物技术、生物与环境、生物学与 其他学科交叉的领域

Microbial molecular biology and genetics A clone: a population of cells that are derived asexually from a parental cell and are genetically identical. Genome: all the genes present in cell or virus. Central dogma:dna→rna→ protein transcription translation

Typical Length Scales in Biology IA lO microtubule DNA width width typical animal cell length of DNA in a chromosome

L4: Cooperativity introduction 2 phage model n phage model (Hasty et al.) as example for applying mass action law

Fine tuned model for perfect adaptation spiro et a1.PNAs94,7263-7268(1997) A model of excitation and adaptation in bacterial chemotaxis

Organizational Remarks: ps#2,1b: Correction: Plot k, and for L= 0...2/K L (NOT: Plot ka and for L 0...2KL) Tomorrow's recitation topic: 'PS #2 support

creation of membrane associated minD first order first order autocatalytic inhibited by (linear, oligomerization) membrane minE, MM)

Review L15 Turing-Gierer-Meinhardt models Local excitation, global inhibition

Note final ps For question 2(a)the value of k'in the final equation(Eq 3b) needs to be rescaled Tuesday lecture will be for questions on the last problem set Juan)