ntroduction of Molecular Biology Genomics 中心法则 Proteomics DNA PROTEIN RNA Functional genomics
Introduction of Molecular Biology 中心法则 RNA PROTEIN DNA Genomics Functional genomics Proteomics
An introduction of gene function I Storing information 2、 Replication 3、 Mutation
An introduction of gene function 1、Storing Information 2、Replication 3、Mutation
Overview of gene expression Gene: ATGAGTAACGCG Nontemplate strand TACTCATTG CGC Template strand Transcription mRNA: AUGAGUAACGCG Translation Protein: MetSerAsnAla
Overview of gene expression
H O H O H O H2N-C-C-0-++HN-C-C-0 H3N-C-C-N-c-C-0+ H20 Peptide bond 肽键的形成
肽键的形成
) ( NOOOO(R an example of protein secondary structure: a-helix
an example of protein secondary structure: а -helix
Carboxyl terminal R terminal N 二D R) R Carboxyl Amino terminal terminal An antiparallel B-sheet
An antiparallel β -sheet
tertiary structure of myoglobin(肌红蛋白)
tertiary structure of myoglobin(肌红蛋白)
The globular domains of immunoglobulin quaternary structure)
The globular domains of immunoglobulin ( quaternary structure )
summary y Proteins are polymers of amino acids linked through peptide bonds y The sequence of amino acids in a polypeptide imary structure)gives rise to that molecules local shape(secondary structure,overall shape (tertiary structure), and interaction with other polypeptides(quaternary structure)
summary Proteins are polymers of amino acids linked through peptide bonds . The sequence of amino acids in a polypeptide (primary structure) gives rise to that molecule , s local shape (secondary structure),overall shape (tertiary structure), and interaction with other polypeptides (quaternary structure)
Transcription (1)Initiation (a) RNa polymerase binds N OVVYVMN to promoter (b)First phosphodiester bond forms (2)Elongation (3)Termination
Transcription