Alternative views on gradient sensing Postma and van hastert. 'a diffusion-translocation model for gradient sensing by chemotactic cells Biophys.J.81,1314(2001) Levchenko and Iglesias. Models of eukaryotic gradient sensing: applications to chemotaxis of amoeba and neutrophils

Review Turing-Gierer-Meinhardt models Local excitation, global inhibition 22r+hq

Wrapping up E coli chemotaxis (L7& L8) Main points of last 2 lectures L7: Biological background what is the function of the individual molecules L8: modeling of all possible chemotactic reactions why doesn't this model reproduce experimentally observed perfect adaptation

L14: 14 Lectures past and 1 1 to go Part 'The cell as a well-stirred bioreactor topICs Lambda phage lysis-lysogeny switch Synthetic genetic switch Switches as memory storage Chemotaxis: perfect adaptation or not? Synthetic genetic oscillators

Mathematical basis of stability analysis =f(x,y) system of two coupled differential equations y=g(x,y) step 1 find nullclines and fixed point(s)

麻省理工大学：《Systems Biology》Review lecture 2 Michaelis-Menten kinetics

Traditional Systems Engineering Process model 16.422 ACQUISITION PHASE UTILIZATION PHASE

Information and the Manager e Data raw facts such as the number of customers Information: data arranged in a meaningful fashion Good information possesses these attributes o Information Quality: measures information accuracy and reliabilit

Outline Merchandising activities Operating cycle of merchandising companies Merchandising cost accounts Inventory systems Merchandise purchases Sales transactions Adjusting and closing entries Task Team of FUNDAMENTAL

Why Statistical Mechanics? Understand predict the physical properties of macroscopic systems from the properties of their constituents Deterministic approach ma F need of 6n coordinates at t: r: and v but typically n= moles (1023)! Ensemble?rather than microscopic detail and its surroundings microcanonical, canonical, grand canonical