1. What are the gene expression stages that can be regulated? (10 points) Regulated stages in gene expression: (1) transcription initiation (the most important stage): RNAP binding of the promoter, transition from the closed complex to the open complex; promoter escape 4’ (2) stages after initiation (elongation and termination) 2’ (3) RNA processing (alternative splicing) in eukaryotes 2’ (4) translation 2’

Q1. Prokaryotic cell E. coli consists of a single closed-circular DNA molecule of 4.6 x 106 bp long. This DNA molecule would be 1.6 mm if the double helix is relaxed. Please describe what strategies does E. coli use to pack such a long molecules into its nucleoid less than a micrometer (mm) in diameter. (20 points)

Q1. Prokaryotic cell E. coli consists of a single closed-circular DNA molecule of 4.6 x 106 bp long. This DNA molecule would be 1.6 mm if the double helix is relaxed. Please describe what strategies does E. coli use to pack such a long molecules into its nucleoid less than a micrometer (mm) in diameter. (20 points)

Your answer should describe what each item is and how it functions in the cell. Diagrams, structure and sequence information could be included in your answer, as necessary. 1. Affinity chromotography 2. microRNA 3. Alternative splicing 4. Insulator 5. Riboswitch 6. Wobble concept 7. Topoisomerase

PART I: DESCRIPTION (2 points each) Your answer should describe what each item is and how it functions in the cell. Diagrams, structure and sequence information should be included in your answer, as necessary

If You Don’t Define the Project, the Project Will Define You One of the first and toughest questions researchers must answer to foster success in the lab is: What do I have to accom￾plish? This requires you to understand your purpose to the

What Are the Symptoms of Acrylamide Poisoning? The initial symptoms of acrylamide poisoning on the skin are peeling of the skin at the point of contact, followed by tingling and numbness in the exposed area. If exposure by any means (touch, ingestion, inhalation) continues, muscular weakness, difficulty maintaining balance

I guess I have to come out to reply to those who concern with the nature rate of unemployment. First, What is the natural rate of unemployment? It is assumed to be the unemployment rate at the steady state or equilibrium. Note that equilibrium here is not referred to the common demand-supply equilibrium, but to a state at which things are not changed, or remain the same. More specifically, suppose we can have an economy that could be expressed by the following dynamic system

1、学什么（What）: 信号(Signal ) 系统(System) 信号处理(Signal Processing) 它们之间的相互关系(their interconnections)

I guess I have to come out to reply to those who concern with the nature rate of unemployment. First, What is the natural rate of unemployment? It is assumed to be the unemployment rate at the steady state or equilibrium. Note that equilibrium here is not referred to the common demand-supply equilibrium, but to a state at which things are not changed, or remain the same. More specifically, suppose we can have an economy that could be expressed by the following dynamic system