§1 Symmetry elements and symmetry operations §2 Groups and group multiplications §3 Point Groups, the symmetry classification of molecules §4 Application of symmetry

一、目的要求: 了解拼合原理在药物结构修饰中的应用。 二、实验原理 磺胺嘧啶银为应用烧伤创面的磺胺药,对绿脓杆菌有强的抑制作用,其特点 是保持了磺胺嘧啶与硝酸银二者的抗菌作用。出用于治疗烧伤创面感染和控制感 染外,还可使创面干燥,结痂,促进愈合。但磺胺嘧啶银成本较高,且易氧化变 质,故制成磺胺嘧啶锌,以代替磺胺嘧啶银。其化学名分别为2-(对氨基苯磺酰 胺基)嘧啶银(sD-Ag)、2-(对氨基苯磺酰胺基)嘧啶锌(sd-zn),化学结构 式分别为:

Reading Assignment for week: Carey & Sundberg: Part A; Chapter 11 Concerted Pericyclic Reactions Pericyclic Reactions: Part–2 Chemistry 206 Advanced Organic Chemistry

• Section 1 Fat Soluble Vitamins • Section 2 Water Soluble Vitamins

I Classification of Rearrangement Reactions II Nucleophilic Rearrangement 1 Wagner-Meerwein rearrangement 2 Pinacolic Rearrangement 3 α-ethandione Rearrangement 4 Beckmann Rearrangement 5 Baeyer-Villiger Rearrangement III Electrophilic Rearrangement

Section K Lipid metabolism K1. Structures and roles of fatty acids K2 Fatty acid breakdown K3. Fatty acid synthesis K4 Metabolism of triacylglycerols K5. Cholesterol metabolism K6 Lipoproteins

Section M Nitrogen Metabolism M1. Nitrogen Fixation and Assimilation M2. Amino acid metabolism M3. The urea cycle M4. Hemes and chlorophylls

§1 Symmetry elements and symmetry operations §2 Groups and group multiplications §3 Point groups, the symmetry classification of molecules §4 Application of symmetry

The term carbohydrate derives from the fact that many of them have a formula that can be simplified to (CH2O)n. Some of these compounds are chemically modified, however, and do not fit the formula due to the modification

Section L Respiration and Energy L1. Citric acid cycle L2. Electron transport and oxidative hosphory lation L3. Photosynthesis