Review L15 Turing-Gierer-Meinhardt models Local excitation, global inhibition

1. Introduction This section discusses the legal protection of information and the security issues of computer data and electronic information systems and is organised into four parts: First, it focuses briefly on the basic conceptual distinction between information and data, providing a basis of understanding of the primary object of legal and technical means of protection. Second, access to Government information will be discussed

Note final ps For question 2(a)the value of k'in the final equation(Eq 3b) needs to be rescaled Tuesday lecture will be for questions on the last problem set Juan)

Alternative views on gradient sensing Postma and van hastert. 'a diffusion-translocation model for gradient sensing by chemotactic cells Biophys.J.81,1314(2001) Levchenko and Iglesias. Models of eukaryotic gradient sensing: applications to chemotaxis of amoeba and neutrophils

Review Turing-Gierer-Meinhardt models Local excitation, global inhibition 22r+hq

Wrapping up E coli chemotaxis (L7& L8) Main points of last 2 lectures L7: Biological background what is the function of the individual molecules L8: modeling of all possible chemotactic reactions why doesn't this model reproduce experimentally observed perfect adaptation

L14: 14 Lectures past and 1 1 to go Part 'The cell as a well-stirred bioreactor topICs Lambda phage lysis-lysogeny switch Synthetic genetic switch Switches as memory storage Chemotaxis: perfect adaptation or not? Synthetic genetic oscillators

Mathematical basis of stability analysis =f(x,y) system of two coupled differential equations y=g(x,y) step 1 find nullclines and fixed point(s)

麻省理工大学：《Systems Biology》Review lecture 2 Michaelis-Menten kinetics

Traditional Systems Engineering Process model 16.422 ACQUISITION PHASE UTILIZATION PHASE