7.1 Introduction 7.2 Codon-anticodon recognition involves wobbling 7.3 tRNA contains modified bases that influence its pairing properties 7.4 (There are sporadic alterations of the universal code) 7.5 tRNAs are charged with amino acids by synthetases 7.6 Accuracy depends on proofreading 7.7 Suppressor tRNAs have mutated anticodons that read new codons 7.8 The accuracy of translation 7.9 tRNA may influence the reading frame
2.1 Introduction We can think about mapping genes and genomes at several levels of resolution: A genetic (or linkage) map identifies the distance between mutations in terms of recombination frequencies. A linkage map can also be constructed by measuring recombination between sites in genomic DNA
Genes vary in natural populations. Gene Variation Is the Raw Material of Evolution. Selection acts on the genetic variation present in populations, favoring variants that increase the likelihood of survival and reproduction
1. A brief history of understanding protein metabolism; 2. The studies leading to the deciphering of the genetic codes; 3. The pathway leading to the synthesis of a functional protein; 4. Current understanding on protein targeting and degradation
Professor and Chairman Department of Pediatrics, Tongji Hospital Director, Center for the Diagnosis of Genetic Metabolic Diseases Tongji Medical College Huazhong University of Science and Technology Adjunct Professor
he major classes of organic compounds common to living systems are lipids, pro- teins, nucleic acids, and carbohydrates. Carbohydrates are very familiar to us- we call many of them\sugars.\ They make up a substantial portion of the food we eat and provide most of the energy that keeps the human engine running. Carbohy- drates are structural components of the walls of plant cells and the wood of trees. Genetic
The nucleus is the biggest and most important organelle of the cell. The presence of the nucleus is the principal feature that distinguishes eukaryotic from prokaryotic cells Almost eukaryotic cells have the nucleus except mature red blood cells of mammals and sieve cells of high plants etc.. By housing the cell's genome, the nucleus serves both as the repository of genetic information and as the control
