Outline Multiple Sequence AlignmentCarillo-& Lipman, Clustal(W) Position-Specific Scoring Matrices(PSSM) Information content, Shannon entropy Sequence logos Hidden Markov Models Other approaches: Genetic algorithms, expectation maximization, MEME, Gibbs sampler

OUTLINE Definition 2 Causes 3 Basic pathological changes 4 Local signs and general reaction Histological types 6 Inflammatory mediator and chemotaxis 7 Sequels

Hyperemia(充血) Hemorrhage出血 Thrombosis(血栓形成) Embolism(栓塞) infarction(梗死)

Repair(修复) As cells and tissues are being injured, events that contain the damage and prepare the surviving cells to replicate are set into motion

premolar 1. maxillary first premolar 4 4 The biggest one of the premolar, the tip of the facial cusp is located distally to the midl ine

Configuration, mastication, fixedness

One Tnberculosis Two Leprosy Three Typhoid fever Four Bacillary dysentery Five Leptospirsis Siⅸ Epidemic hemorrhagic fever Sever Sexually transmitted diseases

Outline FASTA, Blast searching, Smith-Waterman Psi-Blast Review of Genomic DNA structure Substitution patterns and mutation rates Synonymous and non-Synonymous substitutions Jukes-Cantor Model Kimura's Two-Parameter Model

The Language of genomics CDNAS, ESTS. BACS Alus. etc Dideoxy Method Shotgun Sequencing The 'shotgun coverage equation(Poisson) Flavors of blast BLASTIPNXJ, TBLASTINXI Statistics of High Scoring Segments

Review of DNA Seq. Comparison/Alignment Target frequencies and mismatch penalties Eukaryotic gene structure Comparative genomics applications Pipmaker(2 species comparison) Phylogenetic Shadowing(many species) Intro to DNA sequence motifs