General introduction Gram-negative, obligate intracellular coccobacilli bacteria that infect mammals and arthropods Rickettsiae are transmitted in the arthropods, which serves as both vector and reservior Both dna and rna Is sensitive to antibiotic

Campylobacter Among the most widespread cause of infection in the world Cause both diarrheal and systemic diseases Campylobacter jejuni

Biological Features Structure and chemical composition Developmental cycle Staining properties Antigens Growth and metabolism Characteristics of host-parasite- relationship Classification

Outline Multiple Sequence AlignmentCarillo-& Lipman, Clustal(W) Position-Specific Scoring Matrices(PSSM) Information content, Shannon entropy Sequence logos Hidden Markov Models Other approaches: Genetic algorithms, expectation maximization, MEME, Gibbs sampler

OUTLINE Definition 2 Causes 3 Basic pathological changes 4 Local signs and general reaction Histological types 6 Inflammatory mediator and chemotaxis 7 Sequels

Hyperemia(充血) Hemorrhage出血 Thrombosis(血栓形成) Embolism(栓塞) infarction(梗死)

Repair(修复) As cells and tissues are being injured, events that contain the damage and prepare the surviving cells to replicate are set into motion

premolar 1. maxillary first premolar 4 4 The biggest one of the premolar, the tip of the facial cusp is located distally to the midl ine

Configuration, mastication, fixedness

One Tnberculosis Two Leprosy Three Typhoid fever Four Bacillary dysentery Five Leptospirsis Siⅸ Epidemic hemorrhagic fever Sever Sexually transmitted diseases