3-1 Strength of Alkane Bonds:Radicals CHAPTER 3 vtic cleavage Reactions of Alkanes: Bond-Dissociation Energies B一AB Radical Halogenation,and Reactivity morethan e tomndpred a说gede2eano ic cleavage results in the formation of ions,rathe AB→A+ B A-B ete vtic Cleavage port ion formatio DHHF>HCI≥HBr>HI of ra adicals deter mines the C-H bond (A Sin r trend exists for C-C bonds.) ciation ener Methane>Primary>Secondary>Tertiary C-H Bo CHCH,CH,CH+-101 kcal mot H.+. 8.5 kcal mo C-H Bond WeakerMore Stable Radical CH.CH.CR: 1
1 CHAPTER 3 Reactions of Alkanes: Bond-Dissociation Energies, Radical Halogenation, and Reactivity 3-1 Strength of Alkane Bonds: Radicals Breaking a bond requires heat. This energy is called the bonddissociation energy, DH0, or bond strength. H-H Æ H· + H· ΔH0 = DH0 = 104 kcal mol-1 Radicals are formed by homolytic cleavage. When a bond breaks leaving the bonding electrons equally divided between the atoms, the process is called homolytic cleavage or homolysis: Species containing more than one atom and an unpaired electron are called radicals. Free atoms and radicals exist as intermediates in small concentrations during the course of many reactions but cannot usually be isolated. Heterolyltic cleavage results in the formation of ions, rather than radicals: Homolytic Cleavage: Nonpolar solvents Gas phase Heterolytic Cleavage: Polar solvents (stabilize ions) Electronegativities of atoms support ion formation Dissociation energies, DH0, refer only to homolytic cleavages: Bonds are strongest when overlapping orbitals are of similar energy and size: DH0: HF > HCl > HBr > HI The stability of radicals determines the C-H bond strengths. The bond dissociation energies in alkanes generally decreases with the progression: Methane > Primary > Secondary > Tertiary C-H Bond Stronger Less Stable Radical CH3-H Æ CH3· + H· DH0 = 105 kcal mol-1 CH3CH2-H Æ CH3CH2 · + H· DH0 = 101 kcal mol-1 (CH3)2CH-H Æ (CH3)2CH· + H· DH0 = 98.5 kcal mol-1 (CH3)3C-H Æ (CH3)3C· + H· DH0 = 96.5 kcal mol-1 C-H Bond WeakerMore Stable Radical (A similar trend exists for C-C bonds.) Radical stability increases (and thus the energy required to create them decreases) in the progression: CH3· < primary < secondary < tertiary
3-2 Structure of Alkyl Radicals:Hyperconjugation ohctaSdfe2 ◆CH,·+CHIOLCH.CH ”。g88阳 +CH-+-CH0CC国 elthe of theb eocolnomerer oleum is an important source of alkanes. to alter th on of the C.C. 三 3-4Chlorination of Methane:The Radical Chain ine convert ion of all of th ho heated ttrc sm for the chlorin n of methane involves thre 3.Termination SaCao5aenaeiaotgratromtempenare,the 2
2 3-2 Structure of Alkyl Radicals: Hyperconjugation The relative stabilities of the alkyl radicals can be explained by the overlap between the orbital containing the unpaired electron (p orbital) and a hydrogen bonding orbital on the adjacent carbon atom (sp3 orbital). This overlap is called hyperconjugation. No hyperconjugation Increasing Hyperconjugation Æ Hyperconjugation allows the bonding pair of electrons in the σ bond to delocalize into the partially empty p lobe. The stabilization of radicals by resonance, another type of delocalization involving π orbitals, is considerably stronger. Another factor in the stabilization of secondary and tertiary radicals is the relief of steric crowding as the radical carbon assumes sp2 hybridization. 3-3 Conversion of Petroleum: Pyrolysis High temperatures cause bond homolyis. Both C-H and C-C bonds are ruptured at high temperature in a process called pyrolysis. The resulting radicals can combine to form higher or lower molecular weight compounds, or form alkenes by further hydrogen extraction: Catalysts are often used to accelerate and control pyrolysis reactions: o Zeolite,482 C,2min 3 456 17% 31% 23% 18% 11% Dodecane C + C + C + C + other products ⎯⎯⎯⎯⎯⎯→ Catalysts function by lowering the energy of activation of the reaction, often by changing the reaction mechanism. In addition, catalysts also frequently increase the selectivity of the reaction, increasing the amounts of certain products selectively, compared to the uncatalyzed reaction. Petroleum is an important source of alkanes. Breaking an alkane down into smaller fragments is called cracking. Cracking is used in the processing of crude oil in order to alter the natural hydrocarbon composition to a more useful set of products. The higher boiling point components of crude petroleum are cracked by pyrolysis. Cracking the residual oil fraction yields approximately: 30% gas, 50% gasoline, 20% higher molecular weight oils, and coke. Chlorination of Methane: The Radical Chain Mechanism 3-4 Chlorine converts methane into chloromethane. Chlorine and methane gas do not react unless irradiated using UV light, or heated to a temperature above 300oC. During the chemical reaction, the first product formed is chloromethane, CH3Cl (and HCl). If sufficient chlorine is present, further substitution may occur, forming CH2Cl2, CHCl3, and finally CCl4. The chlorination of methane can be shown to be exothermic: Since this reaction does not occur at room temperature, the activation energy must be high. The mechanism explains the experimental conditions required for reaction. A mechanism is a detailed, step-by-step description of all of the changes in bonding that occur in a reaction. The mechanism for the chlorination of methane involves three stages: 1. Initiation 2. Propagation 3. Termination
chlorination of methanetudied stepby ation Step 1: sr二0mr “ Cgoaaoemsneeauroda TpestaeqentleadnaaPm8r32aeeepsocau Step 2 Themciore atomothe C r:a=a ndupplles thedrivng force orthe +CH,H,+a +a3aH,0+0·-27 ww..ww.nm. 二 X+一R+ X+X一 X+RRX+X· Chloromehe 3
3 The chlorination of methane can be studied step by step. Initiation: The first step in the reaction is the heat- or light-induced homolytic cleavage of a molecule of chlorine (the weakest bond in the mixture). Only a relatively small number of initiation events are required to convert all of the reactants into products. Two subsequent self-sustaining propagation steps occur repeatedly without additional homolysis of Cl2. Propagation Step 1: One of the chlorine atoms abstracts a hydrogen atom from a methane molecule: This abstraction is an endothermic process and the equilibrium is slightly unfavorable. In this case, the activation energy is not high and there is enough heat to overcome the barrier: Propagation Step 2: The methyl radical abstracts a chlorine atom from another Cl2 molecule yielding chloromethane and a new chlorine atom. This step is exothermic and supplies the driving force for the overall reaction. 43 3 Slightly Very Favorable Unfavorable Drives First Reaction CH + Cl CH + HCl CH Cl + Cl + HCl ⋅⋅ ⋅ ˆˆˆˆ†ˆ ˆ ˆ ˆ ˆ ˆ ˆ ˆ ˆ ˆ† ‡ ˆ ˆ ˆ ˆ ˆˆ ‡ ˆ ˆ ˆ ˆ ˆ ˆ ˆ The overall enthalpy change for the two propagation steps is: Chain Termination When two radicals find each other and combine to form a covalent bond they are no longer available to participate in propagating the reaction. The chlorination of methane is an example of a radical chain mechanism. To minimize the production of di- and more highly substituted chloromethane, a large CH4/Cl2 concentration ratio is used
3-5 Other Radical Halogenations of Methane or the irstao the F d Br I TRBLE 3-4 +一+ -51+1+18+3 CH,+飞→OH,:+元 -n-27-24-2 CH+一茶+： of6teotnempcaghereacionmjaeoenchaacterist states (iodine reac These two rules the c he second propagation step is exothermic. -6chlor 正3a产yaa +CH--C:+ -31+1+1w --14 L+→0，X:+H或 -1g-5-6 +B The propagation steps are: CHCH,+.c.-CHCH+.-2 al md H+→CHCH+G=-26km 4
4 3-5 Other Radical Halogenations of Methane Fluorine is most reactive, iodine least reactive. The dissociation energies of F2, Br2, and I2 are all lower than that of Cl2 so each can easily initiate a radical chain. The enthalpies for the first and second propagation steps for the four halogens are: In the first propagation step, the very strong H-F bond results in a strong exothermic reaction for fluorine. The remaining values for Cl, Br, and I reflect the decreasing bond strengths of the HCl, HBr, and HI molecules. Comparing fluorine to iodine: The fluorine reaction has a negligible activation barrier. In the transition state, the fluorine atom is relatively far from the hydrogen and the hydrogen is still very close to its attached carbon atom. The converse is true for the iodine reaction. There, the transition state occurs only when the H-I bond is nearly made and the C-H bond is nearly broken. Early transition states (fluorine reaction) are often characteristic of fast exothermic processes. Late transition states (iodine reaction) are often characteristic of slow endothermic processes. These two rules are known as the Hammond postulate. The second propagation step is exothermic. Fluorine has the most and iodine the least exothermic second propagation step. Notice that the overall enthalpy change for iodination is positive. There is not enough energy released in the second step to make up for the large absorption of energy in the first step. Iodine does not react with methane to form methyl iodide and hydrogen iodide. Chlorination of Higher Alkanes: Relative Reactivity and Selectivity 3-6 The chlorination of ethane proceeds by a radical chain process analogous to that of methane. There is only one product: chloroethane. Δ or hν 0 1 CH CH + Cl CH CH Cl + HCl H 28 kcal mol 33 2 32 ⎯⎯⎯→ Δ =− − The propagation steps are:
hiegaeoeae,heen6myand2saconaen gg9ogeneatosa2eetmc4anhega2gEecondan 学学 2 wwww Caaaioeadyaendwaoa heeioCnteteioftaayoprimayhydroegmatomsth 37seeananRatgalHaogenaiontwhFuoine easUtsreioemcetnomnewmtn2-methyheropane.kt25c 一H+H rd) 5
5 If chlorine atoms extracted and replaced primary and secondary hydrogens with equal ease, the product mixture would contain 3 times as much 1-chloropropane as 2-chloropropane. This would be termed a statistical product ratio. In actuality, secondary C-H bonds (DH0=98.5 kcal mol-1) are weaker than primary C-H bonds DH0 = 101 kcal mol-1). At 25oC the observed product ratio is 43:57 rather than 3:1. Secondary C-H bonds are more reactive than primary ones. In the propane molecule, there are 6 primary and 2 secondary hydrogen atoms. The relative reactivity of secondary and primary hydrogens in chlorinations can be calculated: relative reactivity of yield of product from number of / a secondary hydrogen secondary hydrogen abstraction secondary hydrogens = Relative reactivity of yield of product from a primary hydrogen prim ⎛ ⎞⎛ ⎞ ⎜ ⎟⎜ ⎟ ⎝ ⎠⎝ ⎠ 57/2 = 4 number of 43/6 / ary hydrogen abstraction primary hydrogens ≈ ⎛ ⎞⎛ ⎞ ⎜ ⎟⎜ ⎟ ⎝ ⎠⎝ ⎠ Chlorine exhibits a selectivity of 4:1 in the removal of secondary hydrogen atoms over primary hydrogen atoms at 25oC. The relative reactivity of secondary C-H hydrogens to primary C-H hydrogens depends both on the nature of the extracting species, X·, and the temperature. At 600oC, the chlorination of propane exhibits a statistical distribution of products. Every collision between a chlorine atom and a propane molecule has sufficient energy to lead to reaction. Chlorination is unselective at this temperature and leads to a product ratio governed by statistical factors. Tertiary C-H bonds are more reactive than secondary ones. 2-Methylpropane contains 1 tertiary and 9 primary hydrogen atoms. When chlorinated at 25oC, two products are formed, 2- chloro-2-methylpropane and 1-chloro-2-methylpropane, with yields in the ratio of 36:64% respectively. The relative reactivities of tertiary to primary hydrogen atoms in the reaction can be calculated: relative reactivity of yield of product from number of / a tertiary hydrogen tertiary hydrogen abstraction tertiary hydrogens = Relative reactivity of yield of product from a primary hydrogen primary ⎛ ⎞⎛ ⎞ ⎜ ⎟⎜ ⎟ ⎝ ⎠⎝ ⎠ 36/1 = 5 number of 64/9 / hydrogen abstraction primary hydrogens ≈ ⎛ ⎞⎛ ⎞ ⎜ ⎟⎜ ⎟ ⎝ ⎠⎝ ⎠ The selectivity decreases with increasing temperature, as in the secondary case. The relative reactivities of C-H bonds in chlorinations are roughly: Tertiary:Secondary:Primary = 5:4:1 Selectivity in Radical Halogenation with Fluorine and Bromine 3-7 Consider the reaction of fluorine with 2-methylpropane. At 25oC two products are formed: 2-Fluoro-2-methylpropane : 1-Fluoro-2-methylpropane Observed: 14:86 (~1:6.1) Expected: 1:9 (statistical)
H CH CH CCH+HF nble the radica products,rat Reaction coordinate 3-8 Synthetic Radical Halogenation vely expensiv nd ragen .Unfavorable thermodynamics nty the method of choic 3-Symheti Cndhe Reaction occurs at the mo Earth's surface from high veec le rom abo 6
6 Fluorine displays little selectivity because the transition states for either process are reached very early and have energies and structures similar to each other and to the starting material: Bromination of the same compound is highly selective giving the tertiary bromide almost exclusively. Hydrogen abstractions by bromine atoms have late transition states which resemble the radical products, rather than the reactants. 3-8 Synthetic Radical Halogenation A successful synthetic radical halogenation must take into account: •Selectivity •Convenience •Efficiency •Cost of starting materials and reagents Radical Fluorinations are unattractive: •Relatively expensive •Corrosive •Reactions often violently uncontrollable Radical Iodinations fail: •Unfavorable thermodynamics Radical chlorinations are important: •Inexpensive •Drawback of low selectivity (mixtures of isomers formed) Circumvented by using an alkane with only one type of hydrogen: Di- and higher substitution minimized by using Cl2 as the limiting reagent. Radical bromination is frequently the method of choice. •Liquid •Reaction occurs at the more substituted carbon •Solvents utilized (CCl4, CHCl3, CH2Cl2) are relatively unreactive with bromine. Synthetic Chlorine Compounds and the Stratospheric Ozone Layer 3-9 The ozone layer shields Earth’s surface from highenergy ultraviolet light. The ozone layer occurs in the stratosphere, which lies from about 15 km to 50 km above the Earth’s surface. The ozone layer is responsible for filtering out much of the harmful UV light that would otherwise reach the Earth’s surface. hν 2 2 3 hν 3 2 O 2O 1) O + O O 2) O O + O 3) ⎯⎯→ ⎯⎯→ ⎯⎯→ When present at the surface of the Earth, ozone is considered a pollutant. It is a component of smog where it is produced by the photo-decomposition of NO2 to NO and O, which then reacts with O2 to form O3
chlorine atoms upon utravioet rine has decreased by about% 1ea2xmUmlgt9aeearehi8roe8neoaboswhehcan s in the ozone concentratio abcer1ga5r8cana58%goo2eonenheoe Initiation Step: orld is searching for CFC substitutes. 3-10 Combustion and the Relative Stabilities of Alkanes of CFC's Rabgta6ec2drochlooauorocartoas,HGcsand 3 Important Concepts ith chain ength (there are moreC t9g9s8e 1.Bond Homolysis 2.For Alka anes,tho ond Strength: alm 3. aldtohmically staeth asgeeageadn8go 7
7 CFCs release chlorine atoms upon ultraviolet irradiation. Many common refrigerants are chlorofluorocarbons which can react with UV light and release chlorine atoms. These refrigerants are otherwise quite inert and slowly diffuse through the troposphere up into the stratosphere. Once in the stratosphere, the chlorine atoms formed can catalytically convert ozone back into molecular oxygen, thus depleting the ozone layer. Initiation Step: hν F C Cl F C + Cl 3 3 − ⎯⎯→⋅ ⋅ Propagation Steps: Stratospheric ozone has decreased by about 6% since 1978. •As early as 1978 large reductions in the ozone concentration above Antarctica were noticeable. •Each year since 1995 more than 85% of the ozone in the lower stratosphere over Antarctica is destroyed. •The area affected is 2.5 times the area of Europe and stretches far enough north to affect the southern time of South America. •A reduction of 60% in the ozone concentration above the Arctic region was measured during the winter of 2000. •These reductions have been correlated to the concentration of ClO in the upper atmosphere. The source of the ClO (at least 75%) has been shown to be CFC’s. Other sources of atmospheric chlorine, such as sea spray and volcanoes, have been shown to be minor contributors. The world is searching for CFC substitutes. December 31, 1995 marked the end of the production of CFC’s in the industrial world. Replacing the CFC’s are hydrochlorofluorocarbons, HCFC’s, and hydrofluorocarbons, HFC’s. HCFC’s are more chemically reactive than CFC’s and decompose in the troposphere before reaching the stratosphere. HFC’s have been demonstrated to be safe for the ozone layer and are currently displacing the HCFC’s, some of which could escape decomposition in the troposphere and reach the stratosphere. CFC Substitutes: CH2FCF3 CHClF2 CHCl2CF3 CH3CCl2F CH3CClF2 HFC-134a HCFC-22 HCFC-123 HCFC-141a HCFC-142b 3-10 Combustion and the Relative Stabilities of Alkanes Hydrocarbons, when burned in oxygen, produce CO2 and H2O and large amounts of heat energy. This energy is termed the heat of combustion. 2 CnH2n+2 + (3n+1) O2 Æ 2n CO2 + (2n+2) H2O + heat Measurement of the heats of combustion of hydrocarbons yields information about their bond energies. ΔH0 comb of alkanes increases with chain length (there are more C and H atoms to oxidize). ΔH0 comb of isomeric alkanes is generally not the same, even though they have the same numbers of carbon and hydrogen atoms. Butane -687.4 kcal mol-1 2-Methylpropane -685.4 kcal mol-1 Butane is said to be less thermodynamically stable than its isomer. This difference is due to the difference in bond energies between the contained C-H bonds and C-C bonds present in the two molecules. 3 Important Concepts 1. Bond Homolysis – Yields radicals or free atoms. ΔHo for this process is the bond dissociation energy, DHo. 2. For Alkanes, the C-H Bond Strength: CH3—H > RCH2—H > R2CH—H > R3C—H This is due to the order of increasing hyperconjugative stabilization of the corresponding radicals: CH3· < RCH2 · < R2CH · < R3C · 3. Catalysts – Speed up the establishment of the equilibrium between reactants and products. Catalysts do not change the equilibrium position. 4. Alkanes React with Halogens – (Except iodine) by a radical chain mechanism to give haloalkanes. This involves an initiation step, two propagation steps, and various termination steps
3 Important Concepts Important Concepts esuing inan alky radical and HX. Reactivitios of片 ne C-H Bonds-Under mond Postulate-Fast. material Be 10.Heat of Combus Heat released es 8
8 3 Important Concepts 5. The First Propagation Step – is the slower of the two: A hydrogen atom is extracted from the alkane, resulting in an alkyl radical and HX. • Reactivity increases from I2 to F2. • Selectivity decreases from I2 to F2 • Selectivity decreases with increasing temperature. 6. Hammond Postulate – Fast, exothermic reactions are characterized by early transition states, similar in structure to the starting materials. Slow endothermic reactions are characterized by late transition states, similar in structure to the product materials. 7. ΔHo for a Reaction May Be Calculated – oo o ΔH = DH DH ∑ ∑ bonds broken bonds formed − 3 Important Concepts 8. Radical Halogenation Process – ΔHo equals the sum of the ΔHo values for the propagation steps. 9. Reactivities of Alkane C-H Bonds – Under identical conditions the order follows: CH3-H < RCH2-H < R2CH-H < R3C-H At 25o C the relative reactivities of tertiary, secondary, and primary positions are: Chlorination: 5:4:1 Fluorination: 1.4:1.2:1 Bromination: 1700:80:1 (150o) 10. Heat of Combustion - ΔHo comb. Heat released during the combustion of a substance. Measurements of isomeric compounds provides experimental measure of their relative stabilities