BIOMATERIALS-TISSUE INTERACTIONS BIOMATERIAL TISSUE Strength ize scale IOnm 100nm lum 10 um 100 um Imm Modulus of Elasticity Fracture mechanics

Outline 1. Irreversible injury 2. Regenerative and nonregenerative tissues 3. Antagonistic relation between contraction and regeneration 4. Present theory: Selective inhibition of contraction necessary but not sufficient for regeneration 5. Mechanism

ELEMENTS FOR TISSUE REGENERATIONENGINEERING CELLS Autologous, Adult (pulp and bone marrow stromal stem cell)

Methodology of Organ Synthesis A Skin B Conjunctiva C. Peripheral nerves D. simplest synthetic pathways

A. Symbolism of organ synthesis. B. The central question of organ synthesis. C. What is required to synthesize an organ? D. Trans-organ rules of synthesis

B. Conjunctiva synthesis in vivo (regeneration) 1. Structure and function of conjunctiva. 2. Clinical effects of conjunctival scarring. 3. Anatomically well-defined defect. 4. Synthesis of conjunctival stroma, followed by re-epithelialization

TISSUES COMPRISING JOINTS Permanent Regeneration Prosthesis Scaffold Bone

TISSUES COMPRISING JOINTS Permanent Regeneration Prosthesis Scaffold

JOINT REPLACEMENT PROSTHESES Fit -Anatomy Function -Kinematics; Range of Motion Fixation Bone cement, bone interdigitation with an irregular surface, bone ingrowth into a porous coating Tribology

B. Cell-Matrix Interactions A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?