Cystic fibrosis channels. The R-domain has more than one function. In addition to it's inhibitory role in Cystic fibrosis is a hereditary disease that channel gating (when unphosphorylated)the causes certain glands to produce abnormal
Images removed due to copyright considerations. See the following: Figure 1 and Table 1 in Reed SI. 2003. Ratchets and clocks: The cell cycle nover ubiquitylation and protein turnover. Nat Rev. Mol. Cell Biol. 4: 855-864. Figure 1 in Bartek J, Lukas J. Mammalian G1-and S-phase checkpoints in response to DNA damage. Curr Opin Cell
Reversible ligation of Ubiquitin and Ubls to other proteins. Figure by MIT OCW. After Figure 1 in Hochstrasser M. Evolution and function of ubiquitin-like protein-conjugation systems. Nat Cell Biol. 2000 Aug:
Figure 2 in Muratani M, Tansey WP. \How the ubiquitin-proteasome system controls transcription.\ Nat Rev Mol Cell Biol. 2003 Mar; 4(3): 192-201. Regulation of TCR by ubiquitylation of RNA polymerase II. Transcription-coupled repair (TCR)is the mechanism through which mutations in actively transcribed genes are preferentially repaired. a Elongating RNA polymerase II (pol II)
