Pathologic significance 1) The high degree of localization of function 2) The same pathologic process to manifest clinically in a completely different way when it infects a different part of the system 3) Pathologic responses are usually limited
Live difficult diagnosis clinical picture, skin biopsy, corneal impression(antibodies only appear very late) Dead- brain sent to Onderstepoort Negri bodies in cytoplasm of brain cells; immunofluorescence virus isolation