Hepatitis virus
Hepatitis virus
Overview of hepatitis virus Virus Virus group Nucleic Mode of infection Severit acid (chronicity) HAV Enterovirus RNA Fecal-oral acute 72(hepatovirus) HBV hepadnavirus DNA Percutaneous ++(chronic) Permucosal HCV FlaviⅤirus RNA Blood(transfusion- +(chronic) associated) HDV B-dependent RNA blood +(chronic) small virus HEⅤ Calicivirus RNA Fecal-oral +(acute) HGV RNA Blood
Overview of Hepatitis Virus Virus Virus group Nucleic acid Mode of infection Severity (chronicity) HAV Enterovirus 72(heptovirus) RNA Fecal-oral +(acute) HBV hepadnavirus DNA Percutaneous; Permucosal ++(chronic) HCV Flavivirus RNA Blood(transfusionassociated) + (chronic) HDV B-dependent small virus RNA blood + (chronic) HEV Calicivirus RNA Fecal-oral +(acute) HGV ? RNA Blood ?
Viral Hepatitis-Overview Type of Hepatitis Source of feces blood/ blood/ feces blood-derived blood-derived blood-derived body fluids body fluids body fluids Route of fecal-oral percutaneous percutaneouspercutaneous fecal-oral transmission permucosal permucosal permucosal Chronic no yes no infection Prevention pre/post pre/post- blood donor pre/post- ensure safe exposure exposure screenIng, exposure drinking immunization immunization risk behavior immunization water modification risk behavior modification
Viral Hepatitis - Overview A B C D E Source of virus feces blood/ blood-derived body fluids blood/ blood-derived body fluids blood/ blood-derived body fluids feces Route of transmission fecal-oral percutaneous permucosal percutaneous permucosal percutaneous permucosal fecal-oral Chronic infection no yes yes yes no Prevention pre/postexposure immunization pre/postexposure immunization blood donor screening; risk behavior modification pre/postexposure immunization; risk behavior modification ensure safe drinking water Type of Hepatitis
o Human cytomegalovirus e Epstein-Barr virus Herpes simplex virus ● Yellow fever virus o rubella
Human cytomegalovirus Epstein-Barr virus Herpes simplex virus Yellow fever virus Rubella
Hepatitis a virus
Hepatitis A virus
Structure Capsid e Small non ssRNA enveloped [7478 bases) icosahedral particle, 27 nm e 27nm in diameter ● SSRNA
Structure Small, nonenveloped icosahedral particle, 27 nm in diameter ssRNA
Replication o Unlike other picornaviruses, however, HAV is not cytolytic and is released by exocytosis Laboratory isolates of hav have been adapted to growth in primary and continuous monkey kidney cell lines, but clinical isolates are very difficult to grow in cell culture
Replication Unlike other picornaviruses, however, HAV is not cytolytic and is released by exocytosis. Laboratory isolates of HAV have been adapted to growth in primary and continuous monkey kidney cell lines, but clinical isolates are very difficult to grow in cell culture
Resistance Stable to: acid at ph 3 Solvents(ether, chloroform) detergents saltwatergroundwater(months) drying(stable) temperature 4C: weeks 56C for 30minutes: stable 61C for 20minutes: partial inactivation
Resistance Stable to: acid at pH 3 Solvents(ether,chloroform) detergents saltwater,groundwater(months) drying(stable) temperature 4℃: weeks 56℃for 30minutes: stable 61℃for 20minutes: partial inactivation
Resistance Inactivated by chlorine treatment of drinking water formalin(0.35%/, 37C, 72hours) acetic acid(2%0, 4hours) B-propiolactone丙内酯(0.25%1 hours Ultraviolet radiation(2p w/cm/min
Resistance Inactivated by: chlorine treatment of drinking water formalin(0.35%,37℃,72hours) acetic acid(2%,4hours) B-propiolactone丙内酯(0.25%,1hours) Ultraviolet radiation(2μW/㎝2 /min)