Hemorrhogic Fever virus Hantaar Virus or HEMORRhaGic fever with renal syndrome virus( HFRS) Xing Jiang Hemorrhogic Fever Virus Dept of microbiology and parasitology
Hemorrhogic Fever Virus Dept. of microbiology and parasitology Hantaar Virus or HEMORRHAGIC FEVER with renal syndrome virus ( HFRS） Xing Jiang Hemorrhogic Fever Virus
Hantaan Virus (HEMORRHAGIC FEVER With renal syndrome virus
Hantaar Virus (HEMORRHAGIC FEVER with renal syndrome virus )
Morphology o Spherical 80-120nm o Nucleocapsid: Helical lpid envelope 3 segments, 2 proteins nucleocapsid (n), RNA polymerase (L) G2E o Envelope: 2 G1≥ glycoproteins, GI and 人‖ G2
Spherical, 80-120nm Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L') Envelope: 2 glycoproteins, G1 and G2, Morphology
Biological properties SSRNA with long, medium, short segments Antigens 6 serotypes (I-Vi) Resistance: weak BUNYAVIRUSES: ()senselambisense, 3 segments G2 NSm G1 M s Ns
Biological properties 1. ssRNA with long, medium,short segments 2. Antigens 6 serotypes (I- VI) 3. Resistance: weak
Epidemiology Natural host: rodents(deer mouse (Peromyscus maniculatus ), cotton rat (Sigmodon hispidus), marsh rice rat(Oryzomys palustris), white-footed mouse(Peromyscus leucopus), other carriers) Transmission: Droplet and rodent excreta spread 3 Season and district
Epidemiology 1. Natural host : rodents (deer mouse (Peromyscus maniculatus), cotton rat (Sigmodon hispidus), marsh rice rat (Oryzomys palustris) , white-footed mouse (Peromyscus leucopus), other carriers) 2. Transmission : Droplet and rodent excreta spread 3. Season and district
Clinical syndromes Pathogenicity Clinical manifestations Headache 5 phases o Pink in face. neck Fever phase ●上ever marked bleeding tendency Hypotension phase o Lower blood pressure Auria phase o Urine with protein Polyuria phase e multi-organ failure convalescent phase
Clinical syndromes Headache; Pink in face , neck Fever marked bleeding tendency Lower blood pressure Urine with Protein multi-organ failure Pathogenicity Clinical manifestations: 5 phases Fever phase Hypotension phase Auria phase Polyuria phase convalescent phase
o Pathogenesis o Viral direct damage ● Immunopathogenesis o Laboratory diagnosis o Cultivation: Vero-E6 cell and A549 cell Serological diagnosis: IgM/gg Indirect immunofluorescent assay ELISA-IgM o Inactivated vaccine
❑ Pathogenesis Viral direct damage Immunopathogenesis ❑ Laboratory diagnosis Cultivation: Vero-E6 cell and A549 cell Serological diagnosis: IgM/IgG indirect immunofluorescent assay ELISA-IgM ❑ Inactivated vaccine
Xing Jiang Hemorrhogic Fever Virus
Xing Jiang Hemorrhogic Fever Virus
o Spherical, 80-120nm Vector and Host Nucleocapsid: Helical, Animal Host 3 segments, 2 proteins Hyalomma asiaticum nucleocapsid(n), RNA polymerase(l") Season: April and may o Envelope: 2 o Inactivated vaccine glycoproteins, GI and G2
Spherical, 80-120nm Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L') Envelope: 2 glycoproteins, G1 and G2, Vector and Host ➢ Animal Host ➢ Hyalomma asiaticum Season: April and May Inactivated vaccine