Part l: Maintenance of the genome Dedicated to the structure of NA and the processes that propagate, maintain and alter it from one cell generation to the next

Chapter 12 Cell differentiation and Cancer cells Cell differentiation 1. About the concept of cell differentiation The process that a cell changes to carry out a specialized function Marked by: Morphology /Structure/Function

组织的结构 组织结构(organization structure)是指组织 的框架体系,或者构成组织的各要素的 排列组合方式,即组织中各部门及各层 次之间所建立的一种人与人、人与事的 相互关系。 组织结构形式通常被分解为复杂性、正 规化和集权化三种成分

Outline FASTA, Blast searching, Smith-Waterman Psi-Blast Review of Genomic DNA structure Substitution patterns and mutation rates Synonymous and non-Synonymous substitutions Jukes-Cantor Model Kimura's Two-Parameter Model

Review of markov models DNA Evolution CpG Island HMM The viterbi algorithm Real World HMMs Markov models for dna evolution Ch. 4 of Mount

Review of DNA Seq. Comparison/Alignment Target frequencies and mismatch penalties Eukaryotic gene structure Comparative genomics applications Pipmaker(2 species comparison) Phylogenetic Shadowing(many species) Intro to DNA sequence motifs

This lecture: Mount pp 1-7, 29-35, 45-48, Next lecture: Mount pp 8-9, 65-89, 96-115, +more TheProteinDataBank(pdb-http.://ww.pdb.org/)isthesingle worldwide repository for the processing and distribution of 3-D biological macromolecular structure data Berman, H. M, J. Westbrook, Z Feng, G. Gilliland, T N. Bhat

For a number of cross-sections we cannot find stress functions. However, we can resort to an analogy introduced by Prandtl(1903) Consider a membrane under pressure p, Membrane\. structure whose thickness is small compared to surface

Medical Genetics Gene Mutation Change in genes caused by change in structure of the dna

Have considered the vibrational behavior of a discrete system. How does one use this for a continuous structure? First need the concept of..... Influence Coefficients