一、是一种少年儿童常见的结缔组织病 One of the most common connective tissue diseases of children 二、以慢性关节炎(滑膜炎)为主要特点 Characterized by chronic arthritis (synovitis of the joints) 三、多脏器受累,如肝脾肿大、淋巴结肿大、浆膜炎(心包积液)等 Visceral involvement ,such as hepatosplenomegaly, lym- phadenopathy and serositis (pericardial effusion)
ANTITHROMBOTIC PROPERTIES Inhibition of platelet aggregation: PGL NO, ADPase Anticoagulant -binding and inhibition of thrombin: Antithrombin acceleration by heparin-like molecules, thrombomodulin activation of protein C/S, a2-macroglobulin. Fibrinlysis: Tissue plasminogen activator (tPA)
Motional pathway of embolus: Embolus from left heart cavity or arterial system Embolus from right heart cavity or venous system Embolus from portal veins Paradoxical embolism Retrograde ethrombus