Rip: REGULATED INTRAHENBRANE PROTEOLYSis .Site. spacifie membrae. prote2ses Substratey achivated by protcolytc procassing .. SREBP TF controlling rol metabohis IRE1 Unfolded protein response Notch APP \RoP*: REGULATED. UBiQUiTIN/PROTEASOME DEPENDENT PROCESSING\ type ERAD (ER zciakd dxgradatin) process involving proltoly'c procassing:

insolubility. Administration of cystamine, a transglutaminase inhibitor, reduces the To date, 10 neurological diseases, including aggregate formation, retarding the Huntington's and several ataxias, are caused development of neurological phenotype and by the lengthening of glutamine(@) tracts in prolonging the life span of brain cells in various proteins with no obvious functional or transgenic mouse models

Epstein-Barr virus (EBV), is the herpesvirus that causes infectious mononucleosis and is associated with a number of cancers, particularly lymphomas in immunosuppressed persons including persons with AIDS EBV is a ubiquitous virus, so common that it has been difficult to determine whether it is the cause of certain diseases or whether it is simply there as an artifact

Images removed due to copyright considerations. See the following: Figure 1 and Table 1 in Reed SI. 2003. Ratchets and clocks: The cell cycle nover ubiquitylation and protein turnover. Nat Rev. Mol. Cell Biol. 4: 855-864. Figure 1 in Bartek J, Lukas J. Mammalian G1-and S-phase checkpoints in response to DNA damage. Curr Opin Cell

How p53 and Rb pathway function may be disrupted in cancer cells Components of the pathway which are found altered in human cancers are shown in red on the diagram above p53 and Rb themselves may be inactivated by gene mutation (loss of both copies or also as in familial retinoblastoma and Li-Fraumeni syndrome where there are inherited mutations in one copy of Rb or p53 gene respectively. Alternatively

DISCOVERy OF THE ROLE OF UBIQUITIN IN PROTEIN DEGRADATION HISTORICAL FACTS Courtesy of Sam Griffiths-Jones. Used with permission Source: \Peptide models for protein beta-sheets hD thesis, University of Nottingham, 2001 8(1975)Ubiquitin was first isolated by Gideon Goldstein and colleagues from the thymus(reason why it was originally thought to be a thymic hormone)

第一节氨基酸 一、分类、命名和构型 1.分类:按烃基类型可分为脂肪族氨基酸,芳香族氨基酸,含杂环氨 基酸。 按分子中氨基和羧基的数目分为中性氨基酸,酸性氨基酸, 碱性氨基酸

物质在生物体内进行氧化称生物氧化,主要指糖、脂肪、蛋白质等在体内分解时逐步释放能量,最终生成CO2和H2O的过程

物质在生物体内进行氧化称生物氧化，主要指糖、脂肪、蛋白质等在体内分解时逐步释放能量，最终生成CO2和 H2O的过程

一、化学交换现象 1 一个核在A,B两个不同状态下的交换 2 A,B两个不同状态: (1)处于不同分子, 如蛋白质上的NH,OH质子与水中质子交换 (2)同一个分子的不同构象 如顺式与反式异构体