我们要认识的主题是营养,营养成分是人体(包括 )的物质基础,同样也是人体抗郁疾病能力基础。 人体的免疫器官和免疫细胞也依赖于营养物质,了解 营养与健康的科学内涵,可以帮助我们保持健康,远 离疾病,是人生中最重要的事

系统性红斑狼疮(Systemic lupus erythematosus,SLE)是一种病因未 明的自身免疫性结缔组织病,临床主 要特点为患者体内产生多种致病性自 身抗体和免疫复合物,造成多系统、 多脏器的损伤。SLE常被称为自身免疫 性疾病的原型

SLE是一种具有明显遗传景,由感染、激素等等触发因子与外环境(紫外线等理化因子)内环境(人体免疫状况诸多因素的共同相互作用而引起机体免疫调节紊乱自身免疫性疾病

defense system that has evolved to protect animals from invading pathogenic microorganisms and ancer. It is able to generate an enormous variety of cells and molecules capable of specifically recognizing and eliminat ing an apparently limitless variety of foreign invaders. These cells and molecules act together in a dynamic network whose omplexity rivals that of the nervous system. Functionally, an immune response can be divided into two related activities--recognition and response. Immune

cell receptor when complexed with MHC,are called antigens. The molecular properties of antigens and he way in which these properties ultimately contribute to immune activation are central to our understanding of the mmune system. This chapter describes some of the molecu- Complementarity of Interacting Surfaces of Antibody(left) lar features of antigens recognized by B or T cells. The chap and Antigen(rig ter also explores the contribution made to immunogenicity by the biological system of the host; ultimately the biological system determines whether a molecule that combines with a a Immunogenicity Versus Antigenicity Bor T cells antigen-binding receptor can then induce an im

Kappa Light-Chain Gene Rearrangement the vertebrate immune system is its ability to respond to an apparently limitless array of for eign antigens As immunoglobulin(Ig)sequence data accu- a Genetic Model Compatible with Ig Structure mulated, virtually every antibody molecule studied was found to contain a unique amino acid sequence in its vari a Multigene Organization

possesses a tightly linked cluster of genes. the ma jor products play roles in intercellular recognition and in dis on of vesicular Stomatitis Virus Peptide (top) Class I Molecule H-2K General Organization and Inheritance of the MHC MHC Molecules and Genes that Detailed Genomic Map of MHC Genes Cellular Distribution of MHC Molecules antigens of Regulation of MHC Expression implicated MHC and Immune Responsiveness natural killer

the B-cell rec and diffict Interaction of aB TCR with Class II MHC-Peptide Early Studies of the T-Cell Receptor complex cel aB and yo T-Cell Receptors: Structure and Roles ficity. Sec Organization and Rearrangement of TCR Genes gen alone by the major histo T-Cell Receptor Complex: TCR-CD3 erty precludes pur

production of plasma cells and memory B cells can be divided into three broad stages: generation of mature, immunocompetent B cells(maturation), activa- Initial Contact between b and T cells tion of mature B cells when they interact with antigen, and differentiation of activated B cells into plasma cells and memory B cells. In many vertebrates, ng humans B-Cell maturation and mice, the bone marrow generates B cells. This process

of the humoral branch of the immune system Research on complement began in the 1890s, when Jules bordet at the institut pasteur in paris showed that sheep antiserum to the bacterium vibrio cholerae caused lysis of the bacteria and that heating the antiserum destroyed its bacteriolytic activity. Surprisingly, the ability to lyse the bacteria was restored to the heated serum by adding fresh serum that contained no antibodies directed a The Functions of Complement