Medical genetics 2. Inborn errors of metabolism Inborn errors of metabolism are are genetic disorders in which the body cannot turn food into energy (metabolize food) normally. The disorders are usually caused by defects in the enzymes involved in the biochemical pathways that break down food components

Expression of many genes in cells are requlated Housekeeping genes expressed constitutively, essential for basic processes involving in cell replication and growth. Inducible genes expressed only when they are activated by inducers or cellular factors

Epidemiology 6th leading cause of death in U.S. Number one Among the infectious diseases 6 million patients annually in US Incidence 5~10/1,000/year Mortality in OPD patients 1-5 % but Inpatients 25%, ICU 50-60%

Lecture 1 Introduction and classification of geometric modeling forms 1.1 Motivation Geometric modeling deals with the mathematical representation of curves, surfaces, and solids necessary in the definition of complex physical or engineering objects. The associated field of computational geometry is concerned with the development, analysis, and computer implemen tation of algorithms encountered in geometric modeling. The objects we are concerned with in engineering range from the simple

The medicinal use of plants has been discovered more than 2000 years ago. Greek physician Dioscorides described the use of opium, in which morphine is the main component. In 1806, morphine was isolated from opium. In 1820, quinine was isolated from the bark of the cinchona tree

Epidemiology of CHD Prevalence CHD occurs in 0.5-0.8% of live births; The incidence is higher among stillborns 死产(3-4%), abortuses流产(10-25%),and premature infants (about 2% excluding PDA); About 2-3 in 1,000 newborn infants will be symptomatic with heart disease in the first year of life

Purulent Meningitis Acute infection of central nervous system(CNS). 90% of cases occur in the age of 1 mo-5yr. The inflammation of meninges caused by various bacteria. Common features in clinical practices include: fever, increased intracranial pressure, meningeal irritation

What is FBG? An in-fibre Bragg grating is constructed by varying the refractive index of the core lengthwise along the fibre. Light of the specified wavelength traveling along the fibre is reflected from the grating back in the direction from which it came. Wavelengths which are not selected are passed through with little or no attenuation

Innovation, Technological Change and Competition Technology refers to the skills, knowledge experience, body of scientific knowledge, tools, computers, machines used in the design and production of goods and services. Ouantum technological change: fundamental shift in technology that results in innovation The Internet and genetic engineering are examples

I Let L= 1.25 H in Fig. 6-11, and determine v(t)if v(0) 1(02)=20A L 0.05F ig 6-11 For prob. I 2(a)What value of L in the circuit of Fig 6-11 will result in a transient response of the form, v(t)