Endocrinology (1) Roughly a hundred years ago, Starling coined the term hormone to describe secretin, a substance secreted by the small intestine into the blood stream to stimulate pancreatic secretion. In his Croonian Lectures, Starling considered the endo￾crine and nervous systems as two distinct mechanisms for coordination and control of organ function

Contents Normal anatomy,physiology and metabolism of the kidney Clinical manifestation of renal disease Diagnosis and treatment

Classification Prerenal ARF Intrinsic renal ARF Postrenal ARF

Anemia of increased destruction Normochromic, normochromic anemia Shortened RBC survival Reticulocytosis--Response to increased RBC destruction Increased indirect bilirubin Increased LDH

Definition Absent iron-store hemoglobin synthesis↓ A microcytic and hypochromic anemia The most common nutritional anemia

Definition：A group of neoplastic diseases of lymphoid tissues Classification： Hodgkin′s Disease, HD (Hodgkin′s Lymphoma) Non Hodgkin ′s Lymphoma,NHL) General considerations

RF negtive low back pain and stiffness other joints enthesitis familial aggregation

Overview Definition : Osteoporosis is a bone disease in which the amount of bone is decreased and the structural integrity of trabecular bone is impaired. Cortical bone becomes more porous and thinner. This makes the bone weaker and more likely to fracture

DIAGNOSIS AND CLASSIFICATION Anemia is an absolute decrease in hematocrit , hemoglobin concentration, or the RBC count. Anemia is not a diagnosis, but a sign of underlying disease

HEART FAILURE – the pathophysiological state in which the heart is unable to pump blood at a rate commensurate with the requirement of the metabolizing tissues or can do so only from an elevated filling pressure. – Usually caused by a defect in myocardial contraction (myocardial failure)