Lymphoma Zhongshan Hospital Fudan University Zou Shanhua
Lymphoma Zhongshan Hospital ,Fudan University Zou Shanhua
General considerations Definition: A group of neoplastic diseases of lymphoid tissues Classification: Hodgkin′ s Disease,HD ( Hodgkin′ s Lymphoma) Non Hodgkin 's Lymphoma, NHL)
Definition：A group of neoplastic diseases of lymphoid tissues Classification： Hodgkin′s Disease, HD (Hodgkin′s Lymphoma) Non Hodgkin ′s Lymphoma,NHL) General considerations
General Considerations Clinical Features Painless, progressive lymphadenectasis Fever, wasting, night seat; cachexia Splenohepatomegalia epidemiology: Incidence: urban /rural:male/female: age ID8~11%;NHL90
Clinical Features： Painless,progressive lymphadenectasis Fever,wasting,night seat；cachexia Splenohepatomegalia Epidemiology： Incidence： urban / rural;male/female;age HD 8～11％；NHL 90% General Considerations
Etiology and Pathogenesis Virology: EB virus→ Burkitt lymphoma、HD HTLV.I→→ATL HTLV-- Mycosis fungoides
Virulogy: EB virus→Burkitt lymphoma、HD HTLV-Ⅰ→ATL HTLV-Ⅱ→Mycosisfungoides Etiology and Pathogenesis
Etiology and Pathogenesis Immune States of host Immune deficiency/immune suppression Mechanism: Antigenic stimulction-> lymphadenosis(modulation \) -,infinite proliferation → lymphoma
Immune States of Host： Immune deficiency/immune suppression Mechanism：Antigenic stimulction → lymphadenosis(modulation↓ ) → infinite proliferation →lymphoma Etiology and Pathogenesis
Classification of Lymphoma HD: Reed-Sternberg(r-s) Cell Rye classification, 1966 Lymphocyte predominance Nodular sclerosis Mixed cellularity Lymphocyte depletion
HD：Reed-Sternberg(R-S) Cell Rye Classification ，1966 Lymphocyte predominance Nodular sclerosis Mixed cellularity Lymphocyte depletion Classification of Lymphoma
Classification of Lymphoma NHLE IwF,1982 REAL, 1994 wHO,2000
NHL： IWF，1982 REAL，1994 WHO，2000 Classification of Lymphoma
Working formulation Low-grade lymphoma A. small lymphocytic, consistent with chronic lymphocytic leukemia plasmacytoid B follicular, predominantly small cleaved cell diffuse areas sclerosis C follicular, mixed small cleaved and large cell diffuse areas sclerosis
Working formulation Low-grade lymphoma A. small lymphocytic, consistent with chronic lymphocytic leukemia plasmacytoid B. follicular, predominantly small cleaved cell diffuse areas sclerosis C. follicular, mixed small cleaved and large cell diffuse areas sclerosis
Working formulation Intermediate-grad lymphoma D follicular, predominantly large cell diffuse areas sclerosis Ediffuse, small cleaved cell sclerosis F diffuse, mixed small and large cell sclerosis epithelioid cell com ponent G. diffuse, large cell cleaved celll noncleaved cell sclerosis
Working formulation Intermediate-grad lymphoma D. follicular, predominantly large cell diffuse areas sclerosis E. diffuse, small cleaved cell sclerosis F. diffuse, mixed small and large cell sclerosis epithelioid cell component G. diffuse, large cell cleaved cell noncleaved cell sclerosis
Working formulation High-grade lymphoma H. mmunoblastic, large cell plasmacytoid clear cell polymorphous epithelioid cell component lymphoblastic, convoluted or nonconvoluted cell J. small noncleaved cell. burkitts or non -Burkitts
Working formulation High-grade lymphoma H. mmunoblastic, large cell plasmacytoid clear cell polymorphous epithelioid cell component I. lymphoblastic, convoluted or nonconvoluted cell J. small noncleaved cell, Burkitt's or non-Burkitt's