Systemic Lupus Erythematosus Zhongshan Hospital 於强
Systemic Lupus Erythematosus Zhongshan Hospital 於强
Types of lupus △ Discoid ▲ Systemic ▲Drug- induced
一. Types of lupus ▲ Discoid ▲ Systemic ▲ Drug-induced
Characteristic of disease ▲ Atuoimmune Target tissue damage: connection tissue(shin、 Joint、 muscles) A Predominantly population: women during their reproductive year 90% A morbidity 70 per 100, 000
二. Characteristic of disease: ▲ Atuoimmune ▲ Target tissue damage: connection tissue (shin、Joint、 muscles) ▲ Predominantly population： women during their reproductive year 90% ▲ morbidity：70 per 100，000
三. Pathogenic factor A Susceptibility gene: HLA-DR3 A Environmental Factors ultraviolet light food c drugs hydralazine procainamide D-penicillamine Sex hormone Infections agents
三. Pathogenic factor ▲ Susceptibility gene：HLA-DR3 ▲ Environmental Factors： a. ultraviolet light b. food c. drugs hydralazine procainamide D-penicillamine ▲ Sex hormone ▲ Infections agents
四. pathogenesis unclear
四. pathogenesis unclear
Susceptibility gene Environmental Factors/Sex hormone Helper T cell activity Hyperactivated B cell Immune complex Self antibody t self antigens Multiple system involvement vasculitis
Susceptibility gene Environmental Factors Sex hormone Helper T cell activity Hyperactivated B cell Immune complex Self antibody + self antigens Multiple system involvement vasculitis
五. Pathology 1。 vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative C focal segmental lesions d diffuse e membranous f. sclerosing
五. Pathology 1. vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative c. focal segmental lesions d. diffuse e. membranous f. sclerosing
A\ Clinical menifestations of sle - m-Multiple system involvement
六.Clinical menifestations of SLE -----Multiple system involvement
1. Nonspecific symptom o fever o loss of weight o inertia
1. Nonspecific symptom ● fever ● loss of weight ● inertia
2 Skin and mucosa e skin symptoms in 80% of patients ● specifIc features:40% malar rash discoid rash o nonspecific features 60% ● photosensitivity40% o baldness 40% oral ulcer 60%/ Raynaud's phenomenon
2.Skin and mucosa ● skin symptoms in 80% of patients ● specific features: 40% malar rash discoid rash ● nonspecific features 60% ● photosensitivity 40% ● baldness 40% ● oral ulcer 60% ● Raynaud’s phenomenon