一、 MHC分子的基本结构与组织分布 Stucture and Cellular Distribution of MHC Molecules 二、 人MHC基因的结构与多样性 Structure and Polymorphism of Human MHC 三、 MHC分子的抗原肽结合单位 Peptide-Binding Unit of MHC Molecules 四、 蛋白质抗原的处理和递呈 Processing and Presentation of protein Antigens
the early vaccination trials of Edward Jenner and oneering efforts, vac nce of diseases such ng cougl Vaccination with DN A Active and Passive Immunization Designing Vaccines for Active Immunization mWhole-Organism Vaccines Purified Macromolecules as Vaccines Recombinant-Vector Vaccines DNA Vaccines Multivalent Subunit Vaccines mmon usage. Experience has shown that not every vaccine
susceptible host, a series of coordinated events must rcumvent both innate and adaptive immunity. One of the first and most important features of host innate immunity is the barrier provided by the epithelial surfaces of the skin and the lining of the gut. The difficulty of penetrat- ing these epithelial barriers ensures that most pathogens never gain productive entry into the host. In addition to pro viding a physical barrier to infection, the epithelia also pro duce chemicals that are useful in
part of the body to another. This is espe- ially true of lymphocytes, which circulate ly in the blood and lymph and, in common with at sites o Lymphocytes Attached to the Surface of a High-Endothelial Venule sLymphocyte Recirculation Cell-Adhesion Molecules Neutrophil Extravasation Lymphocyte Extravasation Chemokines-Key Mediators of Inflammation Other Mediators of Inflammation The Inflammatory Process
body. These organs can be classified functionally nto two main groups. The primary lymphoid organs provide appropriate microenvironments for the development and maturation of lymphocytes. The secondary lymphoid organs rap antigen from defined tissues or vascular spaces and are sites where mature lymphocytes can interact effectively with that antigen. Blood vessels and lymphatic systems connect these organs, uniting them into a functional whole Carried within the blood and lymph and populating the Macrophage Interacting with
of the humoral branch of the immune system Research on complement began in the 1890s, when Jules bordet at the institut pasteur in paris showed that sheep antiserum to the bacterium vibrio cholerae caused lysis of the bacteria and that heating the antiserum destroyed its bacteriolytic activity. Surprisingly, the ability to lyse the bacteria was restored to the heated serum by adding fresh serum that contained no antibodies directed a The Functions of Complement
