Disorders of fluid and eletrolyte meta bolism 2005-3-10 Huashan Hospital, Fudan University
1 Disorders of Fluid and eletrolyte Metabolism 2005-3-10 Huashan Hospital,Fudan University
Water and Sodium metabolism Control of water excretion Control of sodium excretion Hyponatremia and hypernatremia
2 Water and Sodium Metabolism • Control of water excretion • Control of sodium excretion • Hyponatremia and hypernatremia
Control of water excretion Regulation of thirst Antidiuretic hormone
3 Control of Water Excretion • Regulation of thirst • Antidiuretic hormone
Control of sodium excretion Nephron segmental reabsorption Regulation of sodium balance
4 Control of Sodium Excretion • Nephron segmental reabsorption • Regulation of sodium balance
Nephron Segmental reabsorption Glomerulotubular balance Proximal tubule Henle's loop Distal convoluted tubule Collecting tubule
5 Nephron Segmental reabsorption • Glomerulotubular balance • Proximal tubule • Henle’s loop • Distal convoluted tubule • Collecting tubule
Regulation of Sodium balance Extrarenal mechanisms intrarenal mechanisms
6 Regulation of Sodium Balance • Extrarenal mechanisms • intrarenal mechanisms
Extrarenal mechanisms Renal nerves Renin-angiotensin System Atrial natriuretic peptide Vasopressin Endogenous Na-K-ATPase inhibitors
7 Extrarenal mechanisms • Renal nerves • Renin-angiotensin System • Atrial natriuretic peptide • Vasopressin • Endogenous Na-K-ATPase inhibitors
intrarenal mechanisms Renal hemodynamics Physical factors Prostaglandins Kallikrein-kinin system Endothelium-derived factors
8 intrarenal mechanisms • Renal hemodynamics • Physical factors – Prostaglandins – Kallikrein-kinin system – Endothelium-derived factors
Hyponatremia Etiology and classification Clinical features Treatment
9 Hyponatremia • Etiology and classification • Clinical features • Treatment
Etiology and Classification Isotonic hyponatremia Hypertonic hyponatremia hypotonic hyponatremia
10 Etiology and Classification • Isotonic hyponatremia • Hypertonic hyponatremia • hypotonic hyponatremia