Diseases of hematopoitic and lymphoid system淋巴造血糸统疾病 · Red cell disorders · White cell disorders* Bleeding disorders Disorders that affect the spleen and thymus
Diseases of hematopoitic and lymphoid system 淋巴造血系统疾病 • Red cell disorders • White cell disorders* • Bleeding disorders • Disorders that affect the spleen and thymus
Characteristics The organs and tissues are not confined to a single anatomic site The cells are constantly in "traffic The diseases often appear as systemic involvements
Characteristics • The organs and tissues are not confined to a single anatomic site. • The cells are constantly in “traffic”. • The diseases often appear as systemic involvements
White cell disorders Non-Neoplastic Disorders Reactive lymphoid hyperplasia(lymphadenitis Reactive leukocytosis类白血病反应 · Neoplastic disorders lymphomas淋巴瘤 myeloid neoplasms髓性肿瘤 Histiocytic and dendritic- cell neoplasms组织 细胞与树突状细胞瘤
White cell disorders • Non-Neoplastic Disorders - Reactive lymphoid hyperplasia (lymphadenitis) - Reactive leukocytosis 类白血病反应 • Neoplastic Disorders - lymphomas 淋巴瘤 - myeloid neoplasms 髓性肿瘤 - Histiocytic and dendritic-cell neoplasms 组织 细胞与树突状细胞瘤
Lymph node reactive hyperplasia/non-specific lymphadenitis ·概念:各种损伤或刺激引起淋巴结的淋巴细胞和组织细胞增生,淋巴结肿大。 病因:感染因子(细菌病毒)、化学药品、毒素、代谢毒性产物、异物 结局:刺激抗原消失,淋巴结结构部分消失
Lymph node reactive hyperplasia/non-specific lymphadenitis • 概念：各种损伤或刺激引起淋巴结的淋巴细胞和组织细胞增生，淋巴结肿大。 • 病因：感染因子（细菌病毒）、化学药品、毒素、代谢毒性产物、异物。 • 结局：刺激抗原消失，淋巴结结构部分消失
淋巴结的特殊感染 淋巴结结核 淋巴结真菌感染(曲菌/新型隐球菌) 组织细胞坏死性淋巴结炎(HHV6)
淋巴结的特殊感染 • 淋巴结结核 • 淋巴结真菌感染（曲菌/新型隐球菌） • 组织细胞坏死性淋巴结炎 （HHV-6)
Benign lymphoid hyperplasia(小结) Non-specific lymphadenitis acute non-specific lymphadenitis chronic non-specific lymphadenitis follicular hyperplasia parafollicular hyperplasia sinus histiocytosis Distinctive infection
Benign lymphoid hyperplasia （小结） • Non-specific lymphadenitis - acute non-specific lymphadenitis - chronic non-specific lymphadenitis follicular hyperplasia parafollicular hyperplasia sinus histiocytosis • Distinctive infection
The WHo Classification of the Lymphoid Neoplasms 1. Precursor B-Cell Neoplasms Precursor-B lymphoblastic leukemia/lymphoma ll Peripheral B-Cell Neoplasms Chronic lymphocytic leukemia/small lymphocytic lymphoma B-cell prolymphocytic leukemia Lymphoplasmacytic lymphoma Splenic and nodal marginal zone lymphomas Extranodal marginal zone lymphoma Mantle cell lymphoma Follicular lymphoma Marginal zone lymphoma Hairy cell leukemia Plasmacytoma/plasma cell myeloma Diffuse large B-cell lymphoma Burkitt lymphoma
The WHO Classification of the Lymphoid Neoplasms I. Precursor B-Cell Neoplasms • Precursor-B lymphoblastic leukemia/lymphoma II. Peripheral B-Cell Neoplasms • Chronic lymphocytic leukemia/small lymphocytic lymphoma • B-cell prolymphocytic leukemia • Lymphoplasmacytic lymphoma • Splenic and nodal marginal zone lymphomas • Extranodal marginal zone lymphoma • Mantle cell lymphoma • Follicular lymphoma • Marginal zone lymphoma • Hairy cell leukemia • Plasmacytoma/plasma cell myeloma • Diffuse large B-cell lymphoma • Burkitt lymphoma
The WHo Classification of the Lymphoid Neoplasms l. Precursor T-Cell Neoplasms Precursor-T lymphoblastic leukemia/lymphoma M Peripheral T-Cell and NK-Cell Neoplasms T-cell prolymphocytic leukemia Large granular lymphocytic leukemia Mycosis fungoides/Sezary syndrome Peripheral T-cell lymphoma, unspecified Anaplastic large cell lymphoma Angioimmunoblastic T-cell lymphoma Enteropathy-associated T-cell lymphoma Panniculitis-like T-cell lymphoma Hepatosplenic yoT-cell lymphoma Adult T-cell leukemia/lymphoma NK/T-cell lymphoma, nasal type NK-cell leukemia
The WHO Classification of the Lymphoid Neoplasms III. Precursor T-Cell Neoplasms • Precursor-T lymphoblastic leukemia/lymphoma IV. Peripheral T-Cell and NK-Cell Neoplasms • T-cell prolymphocytic leukemia • Large granular lymphocytic leukemia • Mycosis fungoides/Sézary syndrome • Peripheral T-cell lymphoma, unspecified • Anaplastic large cell lymphoma • Angioimmunoblastic T-cell lymphoma • Enteropathy-associated T-cell lymphoma • Panniculitis-like T-cell lymphoma • Hepatosplenic γδT-cell lymphoma • Adult T-cell leukemia/lymphoma • NK/T-cell lymphoma, nasal type • NK-cell leukemia
The WHo Classification of the Lymphoid Neoplasms V, Hodgkin lymphoma Classical subtypes · Nodular sclerosis Mixed cellularity Lymphocyte-rich Lymphocyte depletion Lymphocyte predominance
The WHO Classification of the Lymphoid Neoplasms V. Hodgkin Lymphoma • Classical subtypes • Nodular sclerosis • Mixed cellularity • Lymphocyte-rich • Lymphocyte depletion • Lymphocyte predominance
1.概念 Lymphomas- Definition Clonal tumors of mature and immature lymphocyte including B-cells, T-cells and Natural Killer(nk)cells and so on Malignant tumors of immune system Involved organs and tissues Lymphoid organsand tissues Extranodal tissues Bone marrow Peripheral blood
1. 概念 Lymphomas- Definition • Clonal tumors of mature and immature lymphocyte including B-cells, T-cells and Natural Killer (NK) cells and so on. • Malignant tumors of immune system. • Involved organs and tissues: - Lymphoid organsand tissues - Extranodal tissues - Bone marrow - Peripheral blood