Drugs acting on respiratory system Cough antitussive drugs centrally acting peripherally acting Sputum expectorant drugs sputum-diluting drugs mucolytic drugs Asthma antiasthmatic drugs bronchodilators 阝 receptor agonists theophyllines muscarinic antagonists anti-inflammatory drugs glucocorticosteroids mediator release inhibitors
Drugs acting on respiratory system Cough antitussive drugs centrally acting peripherally acting Sputum expectorant drugs sputum-diluting drugs mucolytic drugs Asthma antiasthmatic drugs bronchodilators receptor agonists theophyllines muscarinic antagonists anti-inflammatory drugs glucocorticosteroids mediator release inhibitors
Antiasthmatic drugs Immunological and non-immunological stimuli Airway inflammation bronchoconstriction glucocorticosteroids B2receptor agonists disodium theophylline cromoglycate muscarinic antagonists leukotriene modifiers Airway hyperresponsiveness Wheezing(asthmatic symptoms)
Antiasthmatic drugs Airway inflammation bronchoconstriction Airway hyperresponsiveness Immunological and non-immunological stimuli Wheezing (asthmatic symptoms) glucocorticosteroids disodium cromoglycate leukotriene modifiers 2 receptor agonists theophylline muscerinic antagonists
Antiasthmatic drugs Blood Vessel ucus Transp Ire Cationic Proteins Epithelium Epitiglail Cell D:g9) Recruiting Edg ncreased ■■■圆口■■■圆口■口口 Increased Release of Tachykinins secretion Sensory C Fibers E Inflammatory Cells, E(Mast Cells, Eosinophils ■■■■口■■■■■■■■■■■ Smooth muscle Cysteinyl Leukotrienes ■■■■口■■■■ Contraction and Proliferation Airway pathological changes in pathogenesis of bronchial asthma
Antiasthmatic drugs Airway pathological changes in pathogenesis of bronchial asthma
Antiasthmatic drugs Plasma leak and edema Goblet cell discharg Antigens、 Epithelial shedding T lymphocyte Neutrophil Sense Eosinophil Effete Macrophage Airway pathological changes in pathogenesis of bronch
Antiasthmatic drugs Airway pathological changes in pathogenesis of bronchial asthma
3 Antiasthmatic drugs Why asthma makes it hard to breathe Air enters the respiratory system from the nose and mouth and travels through the bronchial tubes In a non-asthmatic person, In an asthmatic person, the the muscles around th muscles of the bronchial tubes bronchial tubes are relaxed tighten and thicken, and the and the tissue thin air passages become allowing for easy inflamed and mucus. airflow difficult for air to move Inflamed bronchial tube of an asthmatic Normal bronchial tube
3. Antiasthmatic drugs
3 Antiasthmatic drugs Alertor macrophage dendritic ce 新 Mast cell 8少 Mucus plug Epthelial shedding nm mmm nn m ghm Nerve h n m n o activation oOOO Subepithelial fibrosis s Fibroblast Sensory nerve MurIS activation hypersecretion Plasma leakage Hyperplasia Edema cholinergic angiogenesis Bronchoconstriction Airway Hypertrophy/hyperplasia smooth musce Subcutaneous layer
3. Antiasthmatic drugs
Antiasthmatic drugs 口 Bronchodilators β Receptor agonists o Non-selective adrenaline, isoprenaline β2- selective: D moderate-acting: salbutamol, terbutaline D long-acting: salmeterol, formoterol D Theophyllines: aminophylline D Muscarinic antagonists: ipratropium bromide
Antiasthmatic drugs Bronchodilators Receptor agonists Non-selective:adrenaline, isoprenaline 2-selective: moderate-acting: salbutamol, terbutaline long-acting: salmeterol, formoterol Theophyllines: aminophylline Muscarinic antagonists: ipratropium bromide
Drugs used in the treatment ofasthma Classification in Grash Course: Respiratory system (2nd Edition) Relievers Bronchodilators 阝 e agonists short-acting: salbutamol, terbutaline long-acting: salmeterol, formoterol Anticholinergics(muscarinic antagonists) ipratropium bromide Xantines(theophyllines): aminophylline
Drugs used in the treatment of asthma - Classification in Grash Course: Respiratory system (2nd Edition) - Relievers - Bronchodilators 2 agonists short-acting: salbutamol, terbutaline long-acting: salmeterol, formoterol Anticholinergics (muscarinic antagonists): ipratropium bromide Xantines (theophyllines): aminophylline