Analgesics MEX D Opioid analgesics a Synthetic opioid analgesics u Other analgesics
Analgesics Opioid analgesics Synthetic opioid analgesics Other analgesics
General Considerations Pain(疼痛) 躯体痛-快痛,慢痛 内脏痛 神经性痛 口 Analgesia(镇痛): 选择性抑制疼痛感觉, 不影响意识和其他感觉
General Considerations Pain (疼痛)： 躯体痛－快痛，慢痛 内脏痛 神经性痛 Analgesia (镇痛)： 选择性抑制疼痛感觉， 不影响意识和其他感觉
B First Second paIn aIn C fiber Pain As fiber Intensity Time The perception of somatic pain
The perception of somatic pain
Anterolateral tract ax
CGRP 8 Substance P Histamine Dorsal root Bradykinin ganglion neuron Lesion 5HT→ Prostaglandin K °·CGRP Substance P o(Blood vessel Spinal cord Peripheral mechanisms of pain
Peripheral mechanisms of pain
中央后回 内囊 Thalamus 脊髓丘脑束一 触觉小体 头面部感觉 球状小体 脑桥 游高神经末相 颈髓后角损伤出现 节段性感觉障碍 环层小体 延髓 颈髓 皮肤的感觉神经末梢 脊髓丘脑侧束 胸倒索 损伤出现 Conduction 脊髓丘脑传导束性 感觉障碍 pathways of pain 腰髓 脊髓丘脑束在同侧上升 1-2个节段后交又到对侧
Thalamus Conduction pathways of pain
Somatosensory Descend thalamic nuclei Ventroposterolateral Periaqueductal Neospinothalamic tract Rostroventral medulla Spinoreticular tract Descending pathways orsat Ascending pathways Dorsa Spinal cord Ascending
onere Froot A scope oce Cortical locations of pain Los Tempe 1be Sensory homunculus Motor homuncle
Cortical locations of pain
● Measurement of pain
Measurement of pain
Anterior cingulate Insula Noxious Cool grill Warm Noxious heat cold (cool and warm The fMrI imaging of pain
The fMRI imaging of pain