jugular pulmonary atrum vonnie aorta Section Ill Circulation system Trunk and Legs
Section III Circulation system
Overview of Cardiovascular Diseases a Common Cardiac Diseases n Abnormal contractility: Heart failures Abnormal rhythms Arrhythmias u Abnormal blood supply Ischemic heart diseases u Myocardial disorders n Common vascular diseases u Abnormal systematic resistance Hypertension o Dysfunction of coronary vessels Coronary vascular diseases u Dysfunction of cerebral vessels Cerebral ischemia, hemorrhage a Dysfunction of pulmonary vessels Pulmonary hypertension u Dysfunction of peripheral vessels: Peripheral vasculardisorder d Arteriosclerosis
Overview of Cardiovascular Diseases Common Cardiac Diseases Abnormal contractility：Heart failures Abnormal rhythms：Arrhythmias Abnormal blood supply：Ischemic heart diseases Myocardial disorders Common vascular diseases Abnormal systematic resistance：Hypertension Dysfunction of coronary vessels：Coronary vascular diseases Dysfunction of cerebral vessels：Cerebral ischemia, hemorrhage Dysfunction of pulmonary vessels：Pulmonary hypertension Dysfunction of peripheral vessels: Peripheral vascular disorder Arteriosclerosis
Overview of Cardiovascular Drugs u Classification based on target organs/tissues o Heart: Heart failures, arrhythmias, cardiac ischemia. over-load of the heart a Vessels: Vasodilatation vasoconstriction arteriosclerosis n Classification based on the mechanisms o Ion channels. Cal+. Nat. Kt channels o Receptors Adrenoreceptors, AT, receptors, etc. D Enzymes ACEL, Nat-K-ATPase, HMG-CoA reductase o Others. Diuretics
Overview of Cardiovascular Drugs Classification based on target organs/tissues Heart：Heart failures, arrhythmias, cardiac ischemia, over-load of the heart Vessels：Vasodilatation, vasoconstriction, arteriosclerosis Classification based on the mechanisms Ion channels：Ca2+, Na+ , K+ channels Receptors：Adrenoreceptors, AT1 receptors, etc. Enzymes：ACEI, Na+ -K+ -ATPase, HMG-CoA reductase Others：Diuretics
Chapter 6 Cardiovascular drugs Voltage-gated Ca channe/ Caa Part 1 Plasma membrane Calcium ion Drugs affecting ion channels in cvs Ryanodine recept embrane Ca of the SER
Chapter 6 Cardiovascular Drugs Part 1 Drugs affecting ion channels in CVS
Passive Active Nonmediated Transporter mediated A C on智n nne C D (b) Modes ofsolute transmembrane transport
Modes of solute transmembrane transport ion channel
A. General properties of ion channels in CVS u Properties of ion channels a Permeation o Selectivity 0 Gating voltage-gatee chemically gated: ligand-gated phospharylation-gated mechanosensitive nongated background /leak channels
A. General properties of ion channels in CVS Properties of ion channels Permeation Selectivity Gating voltage-gated chemically gated: ligand-gated phospharylation-gated mechanosensitive nongated background / leak channels
cR head group on 0=P-0 transmembrane transpor 66000000000
Ion transmembrane transport
Chemically gated Bind ligand Ligand-gated B Phosphorylation- ga Chemically gated Phosphorylate Phosphrylation- gated: G protein/ secona massagers Dephosphorylate Gating mechanisms C Voltage-gated membrane Voltage-gated of ion channels potential D Stretch or pressure- gated Mechanosensitive Stretch
Gating mechanisms of ion channels Chemically gated Ligand-gated Chemically gated Phospharylationgated: G protein / second massagers Voltage-gated Mechanosensitive
A. General properties of ion channels in CVS u Voltage-gated ion channels d Nat channels a Ca2+ channels K+ channels
A. General properties of ion channels in CVS Voltage-gated ion channels Na+ channels Ca2+ channels K+ channels
Outside cell Inside ce‖ filte voltage sensor General structure of ion channels Pore Structure of electivity filter a-subunit
Structure of -subunit General structure of ion channels voltage sensor filter