Chaper 20 Adrenoceptor Antagonists 1.areceptor antagonists 2.B receptor antagonists 3.a,B receptor antagonists
Chaper 20 Adrenoceptor Antagonists 1. αreceptor antagonists 2. receptor antagonists 3. α, receptor antagonists
AAdrenergic blockers have no effect on the actions of isoproterenol which is a pureβ agonist Pre treatment,:treatment Catecholamine Untreated with an“ya ontrol isoproterenol mm Ha 200 Epinephrine 200 Norepinephrine C-Adrenergic blockers reverse the vaso- constrictive action of epinephrine Epinephrine reversal(肾上腺素作用的圈转
Epinephrine reversal （肾上腺素作用的翻转）
1. at receptor antagonists I 1-1 a1 a receptor antagonists 0 Short-acting Phentolamine酚妥拉明 CH3 N——CH2 HO
1. receptor antagonists 1-1 1 , 2 receptor antagonists Short-acting Phentolamine 酚妥拉明 N N CH3 HO N CH2 H
1. at receptor antagonists 口1 Pharmacology 口(1) Vasodilatation u Blocking a,receptor I (2)Stimulating heart 口 Reflex; blocking a2 receptor NE release个 D 3) Cholinergic and histamine-like effects Contraction of GI smooth muscles, n个 0 Gastric acid secretion
1.1 Pharmacology (1) Vasodilatation Blocking 1 receptor (2) Stimulating heart Reflex；blocking 2 receptor ～NE release (3) Cholinergic and histamine-like effects Contraction of GI smooth muscles, Gastric acid secretion 1. receptor antagonists
1. at receptor antagonists 日1.2 Clinical uses o()Peripheral vascular diseases Acrocyanosis, Raynauds disease D (2) Local vasoconstrictor extravasation
1.2 Clinical uses (1) Peripheral vascular diseases Acrocyanosis, Raynaud’s disease (2) Local vasoconstrictor extravasation 1. receptor antagonists
1. at receptor antagonists D (3) Shock 口 cardiac output↑; d redistribution of blood flow. D shift of fluid from interstitial compartment to vascular compartment; 口 pulmonary pressure↓; u fully adequate replacement of intravascular fluid
(3) Shock cardiac output ; redistribution of blood flow; shift of fluid from interstitial compartment to vascular compartment; pulmonary pressure ; fully adequate replacement of intravascular fluid 1. receptor antagonists
1. at receptor antagonists D (4) Acute myocardial infarction and congestive heart failure after -load v 口 cardiac output个 a (5)Pheochromocytoma I pre-and post-operation 口 diagnosis I (6) Others: impotency
(4) Acute myocardial infarction and congestive heart failure after-load cardiac output (5) Pheochromocytoma pre- and post-operation diagnosis (6) Others: impotency 1. receptor antagonists
1. at receptor antagonists 口1.3 Adverse effects I ()Postural hypotension D(2) Reflex heart stimulation D tachycardia, arrhythmia, angina pectoris 口3) GI reactions u(4Other central depression
1.3 Adverse effects (1) Postural hypotension (2) Reflex heart stimulation tachycardia, arrhythmia, angina pectoris (3) GI reactions (4) Other central depression 1. receptor antagonists
1. at receptor antagonists 口T0 lazoline妥拉唑啉 weak effects more severe adverse effects
Tolazoline 妥拉唑啉 weak effects more severe adverse effects 1. receptor antagonists
1. at receptor antagonists Long-acting Phenoxybenzamin酚羊明」 Longer action duration used for peripheral vasculardiseases anti-shock 口口口 pheochromocytoma improving urinary flow in patients with benign prostatic hypertrophy
Long-acting Longer action duration used for peripheral vasculardiseases anti-shock pheochromocytoma improving urinary flow in patients with benign prostatic hypertrophy Phenoxybenzamine 酚苄明 1. receptor antagonists