Enteroviruses
Enteroviruses
Genera of picornaviruses Enterovirus ◆Po|io Diseases of the human( and other alimentary tract ◆ Coxsackie a and B e.g.polio virus) ◆Echo ◆ Other enteroviruses Rhinovirus Disease of the nasopharyngeal region (e.g. common cold virus) Cardiovirus Murine encephalomyocarditis theiler's murine encephalomyelitis virus Aphthovirus Foot and mouth disease in cloven footed animals Hepatovirus Human hepatitis virus a Others Drosophila c virus, equine rhinoviruses, cricket paralysis virus
Genera of Picornaviruses Enterovirus Polio Coxsackie A and B Echo Other enteroviruses Diseases of the human (and other) alimentary tract (e.g. polio virus) Rhinovirus Disease of the nasopharyngeal region (e.g. common cold virus) Cardiovirus Murine encephalomyocarditis, Theiler's murine encephalomyelitis virus Aphthovirus Foot and mouth disease in cloven footed animals Hepatovirus Human hepatitis virus A Others Drosophila C virus, equine rhinoviruses, cricket paralysis virus
Categories of Enteroviruses Irus Serotypes Clinical Diseases Polioviruses 3 types Asymptomatic infection, viral meningitis, paralytic disease, poliomyelitis Coxsackie a 23 types(A1- Viral meningitis plus, rash, ARD, viruses A22.A24 myocarditis orchitis Coxsackie types(B1-B6) Viral meningitis, but no viruses orchitis Echoviruses 32 types Viral meningitis, with orchitis Other 4 types(68-71) Viral meningitis Enteroviruses
Categories of Enteroviruses Viral meningitis, rash,ARD Other 4 types(68-71) Enteroviruses Viral meningitis, with orchitis Echioviruses 32 types Viral meningitis, but no orchitis Coxsackie B 6 types (B1-B6) viruses Viral meningitis plus, rash, ARD, myocarditis, orchitis 23 types ( A1- A22, A24) Coxsackie A viruses Asymptomatic infection, viral meningitis, paraalytic disease, poliomyelitis Polioviruses 3 types Virus Serotypes Clinical Diseases
Properties of enteroviruses Property Enteroviruses Size(nm) 22-30 Capsid form Icosahedral Polypeptide VP1 VP2, VP3, Vp4 RNa type SS-PS RNA molecular weight 2000, 000-2600,000 Acid Stable*k Optimal temperature for growth(oC) 37 Density in caesium chloride(g/m) 1.34*
Properties of enteroviruses Property Enteroviruses Size (nm) Capsid form Polypeptide RNA type RNA molecular weight Acid Optimal temperature for growth(oC) Density in caesium chloride (g/m) 22-30 Icosahedral VP1, VP2, VP3, VP4 SS-PS 2000,000-2600,000 Stable* 37 1.34*
Transmission o Fecal -oral route: poor hygiene dirty diapers( especially in day- care settings) iNgestion via contaminated food and Water Contact with infected hands Inhalation of infectious aerosols
Transmission Fecal – oral route: poor hygiene, dirty diapers( especially in day-care settings) Ingestion via contaminated food and water Contact with infected hands Inhalation of infectious aerosols
ENTEROVIRUS Entry via aerosol PATHOGENESIS or ingestion Replication Oro-pharyn tonsils Secondary viremia ←| Primary viremia Target tissue circulation Pollo Echo, Polio Hep AEcho Echo Replication Cox Co CoxA CoxA B Peyers patches Brain Meninges Liver Skin Muscle Meningitis Hand foot mouth disease Rash Herpangina Encephalitis Myocardia Hepatitis A Virus in feces Pericarditis Paralysis Pleurodynia
p Pathogenesis of enterovirus infection Replication in Rhino echo oropharynx CoXsacKie, polIO Primary viremia Target Tissue Secondary viremia Skin Muscle Brain Meninges Liver 几 几 Echo E cho P olmo Echo Echo Coxsackie Coxsackie Coxsackie Polio Coxsackie A A B Coxsackie
Pathogenesis of enterovirus infection Rhino,echo, coxsackie,polio Replication in oropharynx Primary viremia Target Tissue Secondary viremia Skin Muscle Brain Meninges Liver Echo Coxsackie A Echo Coxsackie A, B Polio Coxsackie Echo Polio Coxsackie Echo Coxsackie
Pathogenicity (1) ◆ ASYMPTOMATIO All enteroviruses ◆ PARALYSIS- permanent Polio 1, 2,3 Coxsackie a ◆ PARALYSIS- temporary Coxsackie b1-6 ◆ MENINGITIS( aseptic) Echo, coxsackie a and B Polio, entero 71 ◆ ENCEPHALITIS Entero 71 Polio, echo
Pathogenicity(1) ASYMPTOMATIC All enteroviruses PARALYSIS - permanent Polio 1, 2, 3 Coxsackie A7 PARALYSIS - temporary Coxsackie B1-6 MENINGITIS (aseptic) Echo, Coxsackie A and B Polio, Entero 71 ENCEPHALITIS Entero 71 Polio, Echo
Pathogenicity(2) ◆RASH macular Many enteroviruses vesicular-(e.g. Hand Foot Mouth) Coxsackie A SUMMER FEBRILE ILLNESS Many enteroviruses o VESICULAR PHARYNGITIS CHerpangina? Coxsackie a ◆ MYOCARDITIS Coxsackie b
Pathogenicity(2) RASH - macular Many enteroviruses - vesicular - (e.g. 'Hand Foot Mouth') Coxsackie A SUMMER FEBRILE ILLNESS Many enteroviruses VESICULAR PHARYNGITIS ('Herpangina') Coxsackie A MYOCARDITIS Coxsackie B
Pathogenicity 3) 4 EPIDEMIC MYALGIA ( Bornholm) Coxsackie B o UPPER RESPIRATORY INFECTIOn (cold) Echo, coxsackie a ◆ PANCREATITIS Coxsackie B ◆ GASTRO- ENTERITIS Many enteroviusess o CONJUNCTIVITIS (Haemorrhagic) Entero 70 ◆ HEPATITIS Entero 72 (hepatitis a virus)
Pathogenicity(3) EPIDEMIC MYALGIA ('Bornholm') Coxsackie B UPPER RESPIRATORY INFECTION (cold) Echo, Coxsackie A PANCREATITIS Coxsackie B GASTRO-ENTERITIS Many enteroviusess CONJUNCTIVITIS (Haemorrhagic) Entero 70 HEPATITIS Entero 72 (hepatitis A virus)