ENDOMETRIAL CANGER
ENDOMETRIAL CANCER
INTRODUCTION o Endometrial cancer is one of the three main malignant tumors, usually occurs between 58-61 years old Accounts for about 7% of female malignant tumors, and 20%-30%of female malignant tumors in reproductive system
INTRODUCTION Endometrial cancer is one of the three main malignant tumors,usually occurs between 58~61 years old. Accounts for about 7% of female malignant tumors,and 20%~30% of female malignant tumors in reproductive system
L Etiology: not very clear i long term and continuous stimulation of estrogen on endometrium over hyperplasia of endometrium constitutional factors ivpostponed menopause v hereditary factor: 20% has family history
I.Etiology:not very clear i.long term and continuous stimulation of estrogen on endometrium ii.over hyperplasia of endometrium iii.constitutional factors iv.postponed menopause v.hereditary factor:20% has family history
. Pathology . macroexamination O diffused type Olocalized type microscopic examination (.endometrioid adenocarcinoma(80%) histological grade G1: nonsquamous solid growths% G2: nonsquamous solid growth 6%~50% G3: nonsquamous solid growth>50%
II.Pathology i.macroexamination (i).diffused type (i).localized type ii.microscopic examination (i).endometrioid adenocarcinoma(80%) histological grade G1:nonsquamous solid growth≤5% G2:nonsquamous solid growth 6%~50% G3:nonsquamous solid growth＞50%
图6-7这个子宫自前壁打开,附件相连,看上去正常,宫底部有一不规则 斑块,这被证明是浅表浸润的内膜腺癌
子宮体腺癌 [标本] 1.子宫增大,壁厚 2.子宫体癌组织 [病理]子宫体腺癌
子宮内膜腺癌晚期 标本]切开子宫前壁 1.子宫腔内几乎全为腺癌病灶 占据,以左角为重,侵犯肌层 至浆膜层 2.病灶为烂肉样,粉色 元151h0ar3456" [病理]子宫内膜腺癌
这是一个分化好的内膜腺癌,有成纤维细胞增生的间质反应,间质内有纤维 母细胞浸润,间质细胞有长核,嗜伊红,看上去呈波纹状,提示间质浸润。腺体复杂 有不典型复层上皮,有的核圆,有的长,局部极性消失
图6-10这是一个分化好的内膜腺癌或I级腺癌的高倍,有细胞复层、极性消失及细 胞不典型,有些核长,长轴垂直于基底膜,其他核圆,中央透亮核仁在有些细胞中见 到,腺体背靠背,只有极少的间