How p53 and Rb pathway function may be disrupted in cancer cells Components of the pathway which are found altered in human cancers are shown in red on the diagram above p53 and Rb themselves may be inactivated by gene mutation (loss of both copies or also as in familial retinoblastoma and Li-Fraumeni syndrome where there are inherited mutations in one copy of Rb or p53 gene respectively. Alternatively
10.1 Basic concepts 10.1.2 Why Select Prestressing in R.C Structure? 10.2 Basic behavior of P.C 10.6 P.C member under uniaxial tension. 10.7.Design of P.C.member under uniaxial tension. 10.8 P.C member resist bending moment
