Genetic Engineering and Biotechnology Genetic engineering: Isolation manipulation and expression of genetic materials. Gene cloning: Isolation and purification of specific genes In vitro recombination=recombinant DNA

Wonder of the Genetic Engineering Expression of luciferase gene in a plant

Below is an electron micrograph of a single gene being transcribed. The DNA strand runs horizontally with RNa transcripts extending vertically outward Image removed due to copyright reasons a)Draw an arrow indicating the direction that the RNA polymerases are

1. What is gene therapy? Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins

第一节 基因的作用 第二节 基因与蛋白质的相互关系 第三节 遗传精细结构 第四节 突变位点分析 第五节 互补 Complementation

Inborn errors of metabolism Overview Disorders in which defects of single gene cause clinically significant blocks in metabolic pathways Many kinds of disorders Lower incidence Clinical manifestations vary widely: mental retardation, seizure, hypotonia, failure to thrive

基因突变是生物界的普遍现象,是新基因的 唯一来源,是生物进化的原材料。 第一节点突变和染色体突变 名词 基因突变( gene mutation):出现在单个基因 内部任何可遗传的改变,又称为点突变( point mutation)。 染色体突变( chromosomes mutation):包含 染色体片段、整条染色体甚至整个染色体组的遗 传变异,称为染色体突变

Review of DNA Seq. Comparison/Alignment Target frequencies and mismatch penalties Eukaryotic gene structure Comparative genomics applications Pipmaker(2 species comparison) Phylogenetic Shadowing(many species) Intro to DNA sequence motifs

Medical Genetics Genes are entities that parents pass to offspring during reproduction

一、前言 二、诱发基因突变的因素 三、基因突变的一般特性 四、基因突变的分子机制 五、DNA损伤的修复