一、果蝇胚胎发育概况 二、胚胎躯体轴线的建立由母体基因决定 三、受精后合子基因的表达 四、Pair-rule基因的表达界定胚胎的类体节 五、体节极性基因(segment polarity genes)与细胞谱系的建立 六、不同体节的发育命运决定于 homeotic selector genes

发育生物学中的一些基本原理；发育生物学中的动物模型；发育生物学中的现代技术。 胚胎的早期发育：卵裂、原肠作用、神经胚作用。 细胞分化的机制：侧重基因表达的调控对组织器官形成和分化的影响。 果蝇躯体轮廓发育的分子机制 四肢动物的肢体的发育 性别决定与生殖细胞

I Systems Microbiology(13 Lectures 7hece∥ as a we∥}- stirred boc/ nem/ca/ reactor Introduction 2 Chemical kinetics, Equilibrium binding, cooperativity L3 Lambda phage L4 Stability analysis L5-6 Genetic switches

Note final ps For question 2(a)the value of k'in the final equation(Eq 3b) needs to be rescaled Tuesday lecture will be for questions on the last problem set Juan)

Review L15 Turing-Gierer-Meinhardt models Local excitation, global inhibition

creation of membrane associated minD first order first order autocatalytic inhibited by (linear, oligomerization) membrane minE, MM)

Organizational Remarks: ps#2,1b: Correction: Plot k, and for L= 0...2/K L (NOT: Plot ka and for L 0...2KL) Tomorrow's recitation topic: 'PS #2 support

Fine tuned model for perfect adaptation spiro et a1.PNAs94,7263-7268(1997) A model of excitation and adaptation in bacterial chemotaxis

L4: Cooperativity introduction 2 phage model n phage model (Hasty et al.) as example for applying mass action law

麻省理工大学：《Systems Biology》Review lecture 2 Michaelis-Menten kinetics