1. The Concept of Germplasm Resources种质资源的概念 Genetic Resources Gene Resources Varietal Resources Gene Bank It refers to all the plant materials used for plant breeding

基因诊断与基因治疗能够在比较短的时间从理论设想变为现实,主要是由于分子生物学 的理论及技术方法,特别是重组DNA技术的迅速发展,使人们可以在实验室构建各种载 体、克隆及分析目标基因。所以对疾病能够深入至分子水平的研究,并取得了重大的进 展。因此在20世纪70年代末诞生了基因诊断(gene diagnosis):随后于1990年美国实施了第 一个基因治疗(gene therapy)的临床试验方案。可见,基因诊断和基因治疗是现代分子生物学 的理论和技术与医学相结合的范例

Similarity of regulation between eukaryotes and prokaryote 1. Principles are the same: signals, activators and repressors, recruitment and allostery, cooperative binding 2. Expression of a gene can be regulated at the similar steps, and the initiation of transcription is the most pervasively regulated step

Problem Set 2 Prof. Gene Chang (For Ph. D students, due on Dec. 9th in the class or TA's office. For M.A. students, due on Dec. 12th, in the class or TA's office. Late turn-in may result in penalty in the grade) 1. The production set is={yy2):y2sy,-

Problem Set 3 Prof. Gene Chang (For Ph. D students, due on Dec. 28th in the class, or TA's office. For M.A. students, due on Dec. 26th, in the class or TA's office. Late turn-in may result in a penalty in the grade) 1. Kland is a Robinson Crusoe type economy. Robinson, as the consumer and the owner of the firm, has the utility function U(x,) =aIn x+ BInI, where is leisure. Robinson's endowment

Chapter 7 Regulation of Gene Expression Regulation of Enzyme Activity Constitutive enzymes -Enzymes induced by specific circumstances Two major modes of regulation in the cell Control the activity of preexisting enzymes Control the amount of an enzyme

There are many ways of cloning a disease gene, depending on what is known about the disease. We will show several typical examples in this part of the lecture

Muscle cells But if in the same organIsm, should have the same DNA per Nerve cells( cell Different cells have different clusters of genes active Development and differentiation of embryos is controlled by signaling molecules that alter gene expression in cells

第一节 癌基因 Oncogenes 第二节 肿瘤抑制基因 tumor suppressor gene 第三节 生长因子 Growth factors

中国医科大学：《医学遗传学》课程PPT教学课件（讲稿）第10章 基因诊断 Gene diagnosis 第二节 基因治疗（Gene theraphy）