1. Understand the neurobiology of pain 1. Transmission/Perception of Pain 2. Regulation of Pain 1. Accentuation 2. Attenuation 2. Distinguish between acute and chronic pain 3. Analgesics pharmacology 1.NMDA受体的作用 2.炎性介质的作用 3.脊髓阿片系统的下调和抗阿片系统的上调 4.中枢敏化 5.中枢去抑制 6.脊髓胶质细胞激活 其它解热镇痛抗炎药 苯胺类 有机酸类 吡唑酮类