SKⅡN
SKIN
skin（largestorgan）wepidermisconstitution:epidermisdermisdermisfunction:protectionsensoryhypodermregulationissynthesis环层小体神经束
constitution: epidermis dermis skin（largest organ） epidermis dermi dermis function: protection sensory regulation synthesis thick skin, thin skin dermi s hypoderm is
dermatoglyphics(fingerprints)basicfingerprintpatternslooparchwhorl
dermatoglyphics (fingerprints)
I.EpidermiscorneumkeratinizedstratifiedHucidumgranulosumsquamousepitheliumspinosumconsistof5layers-basalekeratinocytes+nonkeratinocytes
corneum lucidum granulosum I. Epidermis • keratinized stratified squamous epithelium spinosum basale • consist of 5 layers • keratinocytes + nonkeratinocytes
1.StratumbasaleLM:a singlelayer of basophiliccolumarlcuboidal cellsrestonBMEM:ribosome,keratinfilaments,desmosomeandhemi-Stemcell (mitoticactivity)
1. Stratum basale LM: a single layer of basophilic columar/cuboidal cells, rest on BM EM: ribosome, keratin filaments, desmosome and hemiStem cell (mitotic activity)
2.StratumspinosumLM:5-10 layers,polygonalspinousprocessesNu: round, centerlessbasophilicEM:ribosomesbundled K.F.tratumspinosunlamellar granules;richom8desmosomes
2. Stratum spinosum LM: 5-10 layers, polygonal spinous processes Nu: round, center less basophilic EM: ribosomes bundled K.F. lamellar granules; desmosomes
3.StlatuLM:3-5layers,spindle,strongbasophilicEM: Keratohyalin granules (basophilic, nomembrane);Abundant L.G.(excrete into intercellular space tostrengthenthecellconnection &thickenthe cellmembrane)
3. Stratum granulosum LM: 3-5 layers, spindle, strong basophilic EM: Keratohyalin granules (basophilic, no membrane); Abundant L.G. (excrete into intercellular space to strengthen the cell connection & thicken the cell membrane). desmosome
Skin,thicktrichromeSkin,thin H&Estratumcorneumstratumcorneumstratumgranulosumstratumstratumlucidumgranulosumstratumspinosumstratumspinosumstratumbasalestratumbasaledermislaydermiseosinophilic andtransparent; no nucleus and organella; denselypacked keratinfilaments;desmosome5. Stratum corneum: eosinophilic horny cell, filledwithKoratin
4. Stratum lucidum: 3-4 layers of cell appear eosinophilic and transparent; no nucleus and organella; densely packed keratin filaments; desmosome 5. Stratum corneum: eosinophilic horny cell, filled with Keratin
Cell.Cell.CellCytoplasmR.k.LG.Morph.Junc.KhG.Memb.Ile/ NuDes.+++1 LayerS.ColumHemi-Scat-NormalNormalBasoPhil(+) D.Stered5-10L+D.S.+++PolygonalNormalNormalBasophil.(+)Bundles3-5 LD.SSpindle++Thicker+++++++Dege-BasophilBundlesnerating(+++)D.SFlat.+++MoreDis-thickAcidophil(+)densepackedappearNumerous LFlat.Disap-MorePackedwithkeratinthickAcidophilpearing(++)** LG: lamellated g. Tf: tonofibril KhG: keratohylin g. K: keratin
Cell. Cell. Cytoplasm Cell Morph. Junc. R. LG. K. KhG. Memb. lle / Nu 1 Layer Des. ++ - + - S.Colum Hemi- ScatBasoPhil(+) D.S tered Normal Normal 5-10 L Polygonal D.S. ++ + + - Basophil.(+) Bundles Normal Normal 3-5 L Spindle D.S ++ ++ ++ +++ Thicker DegeBasophil Bundles nerating Basal Spinous Granular Basophil Bundles nerating (+++) Flat. D.S - - +++ - More DisAcidophil(+) dense packed thick appear Numerous L Flat. Disap- Packed with keratin More - Acidophil pearing thick (++) ** LG: lamellated g. Tf: tonofibril KhG: keratohylin g. K: keratin Granular lucidum corneu m
Non-keratinocytes1. Melanocyte2. Langerhans cell3. Merkel cell
Non-keratinocytes 1. Melanocyte 2. Langerhans cell 3. Merkel cell