Development ofthe Urogenital System
Development of evelopment of the Urogenital System Urogenital System
LearningaimsDevelopment of metanephrosDerivatives of urogenital sinusThestepsthatoccurinthedifferentiation of the testes and ovariesCongenital malformations of urogenitalsystem
Learning aims • Development of metanephros • Derivatives of urogenital sinus • The steps that occur in the differentiation of the testes and ovaries • Congenital malformations of urogenital system
Primordia:Intermediate mesodermyolk sacJendodermstalkextra10embryonicmesoderm3
Primordia: Intermediate mesoderm
中肾峭Mesonephric ridge尿生殖嵋Urogenital生殖腺ridgeGonadal ridgeCervicalpart→nephromereCaudal part→nephrogeniccords生殖结节Genital tubercleUrogenitalridgegonadal ridge mesonephricridge(inner)(outer)
Cervical part → nephromere Caudal part → nephrogenic cords Urogenital ridge gonadal ridge (inner) mesonephric ridge (outer)
?横断面Transection中肾管Mesonephricduct
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I Development ofUrinary System1. Development of Kidney and UreterMthreestages:Pronephrostransitory structureMesonephrosMetanephros→definitive kidney
1. Development of Kidney and Ureter ⅠDevelopment of Urinary System three stages: Pronephros Mesonephros Metanephros transitory structure definitive kidney
1.1Pronephros (forekidney):Nephromere → pronephric tubules and duct -pronephros → degenerates.VestigalpronephricsyslemMesonephrictubulesMesonephricsystemMesonephricductUreteric budMetanephricsystem
1.1 Pronephros (forekidney): Nephromere → pronephric tubules and duct → pronephros → degenerates
1.2Mesonephros:1) mesonephric ridge → mesonephric ductVestigalpronephricsystemMesonephrictubulesMesonephricsystemIntestinalloop-MesonephrosMesonephricductGonad--MesonephricductUreteric budMetanephricsystem
1.2 Mesonephros: 1) mesonephric ridge → mesonephric duct
2)Mesonephrictubules→mostdisappear1.Neuraltube5.Intestinaltube9.Mesonephric duct (Wolffianduct)10.Mesonephrictubule11.Urogenital ridge
1.Neural tube 5.Intestinal tube 9.Mesonephric duct (Wolffian duct) 10.Mesonephric tubule 11.Urogenital ridge 2) Mesonephric tubules → most disappear
1.3metanephros:definitivekidney1)Primordia: ureteric bud and metanephricblastemaHindgutMesonephrictissueAllantois-MesonephricductUrorectalseptumUretericCloaca-budMetanephricblastema
1.3 metanephros: definitive kidney 1) Primordia: ureteric bud and metanephric blastema