Special embryology(organogenesis)DevelopmentofFacialregionDevelopment of digestive and respiratory systemDevelopmentof urogenital systemDevelopmentofcardiovascularsystem
Special embryology (organogenesis) Development of Facial region Development of digestive and respiratory system Development of urogenital system Development of cardiovascular system
Developmentof Facial region
Development of Facial region
Learningaimsdescribe the various parts that areinvolved in forming the face discuss congenital malformations
Learning aims describe the various parts that are involved in forming the face discuss congenital malformations
Review: Formation of embryonic body
Review: Formation of embryonic body
primitive gutCibacalBuccopharyngealmerhbranemembranecHearttubeLiverbudLungbudMidgutRestsofthebucco-Allantoispharyngealmembrane.DYolk sacVitelline-duct
primitive gut ? ? ?
1.BranchialApparatus(weeks4-5)1.1 Position: both lateral sides of headdorsoventrallyplaced.Embryonicpharynx2123105mesenchyma3
1. Branchial Apparatus (weeks 4-5) 1.1 Position: both lateral sides of head, dorsoventrally placed. Embryonic pharynx mesenchyma
1.2 ComponentsBranchial arches: 6 paired bars of mesenchyme;Branchial grooves: 5 ectoderm invaginations;3) Pharyngeal,pouches: 5 pairs of evaginations frompharyngealendoderm;I membranes: appositional grooves and4)1Branchialpouches
1.2 Components 1) Branchial arches: 6 paired bars of mesenchyme; 2) Branchial grooves: 5 ectoderm invaginations; 3) Pharyngeal pouches: 5 pairs of evaginations from pharyngeal endoderm; 4) Branchial membranes: appositional grooves and pouches
1.3 Development1st pair of branchial arches -→face;2nd, 3rd, 4th, 6th pairs -→ neck (5th-→degenerate)额鼻突额鼻突FrontonasalprominenceFrontonasalprominence鼻板上颌突NasalplacodeMaxillaryprominence上颌突品MaxillaryprominenceStomodeum下颌突下颌突MandibulararchMandibularprominence第2和第3鳃弓心隆起Pharyngealarches,2ndand3rdCardiacbulgeAB
1.3 Development 1st pair of branchial arches → face; 2nd, 3rd, 4th, 6th pairs → neck (5th→degenerate)
2. Development of Face (weeks 4-8)2.1.Primordia:5prominencesaroundstomodeum.FrontonasalprominenceSingle frontonasalprominenceMaxillaryprominencePaired maxillaryStomodeumprominencesPairedmandibularMandibularprominenceprominences
2. Development of Face (weeks 4-8) 2.1. Primordia: 5 prominences around stomodeum. •Single frontonasal prominence •Paired maxillary prominences •Paired mandibular prominences
2.2.Development1)Frontonasalprominence(lowerpart)→nasalplacode→medialnasalprominencenasal pitslateralnasalprominence;FrontalorominenceNasalpit-NasalpitMaxillaryLat.nasalswellingswellingMandibularMed.nasalswellingswellingBAlNasolacrimalgrooveStomodeum
1) Frontonasal prominence (lower part) → nasal placode → medial nasal prominence nasal pits lateral nasal prominence; 2.2. Development