《心肺复苏指南》参考资料（英文版）Part 10-3 Drowning

Circulation Atmegiso tmO Learn and live JOURNAL OF THE AMERICAN HEART ASSOCIATION Part 10.3: Drowning Circulation 2005: 1 12: 133-135; originally published online Nov 28, 2005 DOI: 10.1161/CIRCULATIONAHA 105. 166565 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, Tx 72514 Copyright o 2005 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online ISSN:15244539 The online version of this article, along with updated information and services, is located on the world wide web at http://circ.ahajournals.org/cgi/content/full/112/24suppl/iv-133 Subscriptions: Information about subscribing to Circulation is online at http://circ.ahajournals.org/subsriptions/ Permissions: Permissions Rights Desk, Lippincott Williams Wilkins, 351 West Cam Street. Baltimore MD 21202-2436 Phone 410-5280-4050. Fax: 410-528-8550 En journalpermissions@lww.com Reprints: Information about reprints can be found online at http://www.Iww.com/static/html/reprints.html Downloaded from circ. ahajournals. org by on February 21, 2006

ISSN: 1524-4539 Copyright © 2005 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/CIRCULATIONAHA.105.166565 Circulation 2005;112;133-135; originally published online Nov 28, 2005; Part 10.3: Drowning http://circ.ahajournals.org/cgi/content/full/112/24_suppl/IV-133 located on the World Wide Web at: The online version of this article, along with updated information and services, is http://www.lww.com/static/html/reprints.html Reprints: Information about reprints can be found online at journalpermissions@lww.com Street, Baltimore, MD 21202-2436. Phone 410-5280-4050. Fax: 410-528-8550. Email: Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, 351 West Camden http://circ.ahajournals.org/subsriptions/ Subscriptions: Information about subscribing to Circulation is online at Downloaded from circ.ahajournals.org by on February 21, 2006

Part 10.3: Drowning D wning is a leading preventable cause of unintentional been found to be clinically significant. The most important morbidity and mortality. Although this chapter focuses factors that determine outcome of drowning are the duration on treatment, prevention is possible, and pool fencing has and severity of the hypoxia. been shown to reduce drowning and submersion injury( Class Although survival is uncommon in victims who have undergone prolonged submersion and require prolonged re- The most important and detrimental consequence of sub- suscitation, 4, 5 successful resuscitation with full neurologic mersion is hypoxia. Therefore, oxygenation, ventilation, and recovery has occasionally occurred with prolonged submer- perfusion should be restored as rapidly as possible. This will sion in icy water 6-8 For this reason, scene resuscitation require immediate bystander CPR plus immediate activation should be initiated ed and the victim transported to an ED unless of the emergency medical services(EMS)system. Victims there is obvious physical evidence of death who have spontaneous circulation and breathing when they reach the hospital usually recover with a good outcome Modifications to Basic Life Support Victims of drowning may develop primary or secondary for drowning hypothermia. If the drowning occurs in icy (<5C [) No modification of standard BLS sequencing is necessary water, hypothermia may develop rapidly and provide some Some cautions are appropriate, however, when beginning protection against hypoxia. Such effects, however, have CpR for the drowning victim. victims in icy water(see Part 10.4: Hypothermia).2 Recovery From the Water All victims of drowning(see definitions below) who When attempting to rescue a drowning victim, the rescuer require any form of resuscitation(including rescue breathing should get to the victim as quickly as possible, preferably by alone)should be transported to the hospital for evaluation and onveyance(boat, raft, surfboard, or flotati monitoring even if they appear to be alert with effective The rescuer must always be aware of personal safety cardiorespiratory function at the scene. The hypoxic insult Recent evidence indicates that routine stabilization of the can produce an increase in pulmonary capillary permeability cervical spine is not necessary unless the circumstances leading with delayed onset of pulmonary complications. to the submersion episode indicate that trauma is likely(Class Ila). These circumstances include a history of diving, use of a Definitions. Classifications and water slide, signs of injury, or signs of alcohol intoxication. 9 In Prognostic Indicators the absence of such indicators, spinal injury is unlikely. Manual A number of terms are used to describe drowning. to aid cervical spine stabilization and spine immobilization equipment he use of consistent terminology and the uniform reporting may impede adequate opening of the airway, and they compli of data from drowning, the Utstein definition and style of data cate and may delay the delivery of rescue breaths reporting are recommended Drowning is a process resulting in Rescue breathing respiratory impairment from submersion/immersion in a liq- The first and most important treatment of the drowning uid medium. Implicit in this definition is that a liquid/ victim is the immediate provision of ventilation. Prompt interface is present at the entrance of the victim's airway, initiation of rescue breathing increases the victims chance of preventing the victim from breathing air. The victim may live survival. 10 Rescue breathing is usually performed when the or die after this process, but whatever the outcome, he or she unresponsive victim is in shallow water or out of the water.If has been involved in a drowning incident. it is difficult for the rescuer to pinch the victims nose, A victim may be rescued at any time during the drowning support the head, and open the airway in the water, mouth- process and may not require intervention or may receive to-nose ventilation may be used as an alternative to mouth- appropriate resuscitation measures. In either case the drown- to-mouth ventilation. Untrained rescuers should not try to ing process is interrupted. provide care while the victim is still in deep water. The Utstein statement recommends that the term near- Management of the drowning victim's airway and breath- drowning no longer be used. It also de-emphasizes classifi ing is similar to that recommended for any victim of cardio- cation based on type of submersion fluid(salt water versus pulmonary arrest. There is no need to clear the airway of aspirated water, because only a modest amount of water is ave been reported in laboratory conditions, these have not aspirated by the majority of drowning victims and it is rapidly absorbed into the central circulation so it does not act as an ( Circulation.2005;112:Iv-133-Iv-135.) obstruction in the trachea. 5. Some victims aspirate nothing o 2005 American Heart Association because they develop laryngospasm or breath-holding. 5. 12 This special supplement to Circulation is freely available at http://www.circulationaha.org Attempts to remove water from the breathing passages by any means other than suction (eg, abdominal thrusts or the DOI: 10.1161/CIRCULATIONAHA. 105.166565 illich maneuver) are unnecessary and potentially danger IV-133

Part 10.3: Drowning Drowning is a leading preventable cause of unintentional morbidity and mortality. Although this chapter focuses on treatment, prevention is possible, and pool fencing has been shown to reduce drowning and submersion injury (Class I).1 The most important and detrimental consequence of sub￾mersion is hypoxia. Therefore, oxygenation, ventilation, and perfusion should be restored as rapidly as possible. This will require immediate bystander CPR plus immediate activation of the emergency medical services (EMS) system. Victims who have spontaneous circulation and breathing when they reach the hospital usually recover with a good outcome. Victims of drowning may develop primary or secondary hypothermia. If the drowning occurs in icy (
5°C [41°F]) water, hypothermia may develop rapidly and provide some protection against hypoxia. Such effects, however, have typically been reported only after submersion of young victims in icy water (see Part 10.4: “Hypothermia”).2 All victims of drowning (see definitions below) who require any form of resuscitation (including rescue breathing alone) should be transported to the hospital for evaluation and monitoring even if they appear to be alert with effective cardiorespiratory function at the scene. The hypoxic insult can produce an increase in pulmonary capillary permeability with delayed onset of pulmonary complications. Definitions, Classifications, and Prognostic Indicators A number of terms are used to describe drowning. To aid in the use of consistent terminology and the uniform reporting of data from drowning, the Utstein definition and style of data reporting are recommended3: Drowning. Drowning is a process resulting in primary respiratory impairment from submersion/immersion in a liq￾uid medium. Implicit in this definition is that a liquid/air interface is present at the entrance of the victim’s airway, preventing the victim from breathing air. The victim may live or die after this process, but whatever the outcome, he or she has been involved in a drowning incident. A victim may be rescued at any time during the drowning process and may not require intervention or may receive appropriate resuscitation measures. In either case the drown￾ing process is interrupted. The Utstein statement recommends that the term near￾drowning no longer be used. It also de-emphasizes classifi￾cation based on type of submersion fluid (salt water versus fresh water). Although there are theoretical differences that have been reported in laboratory conditions, these have not been found to be clinically significant. The most important factors that determine outcome of drowning are the duration and severity of the hypoxia. Although survival is uncommon in victims who have undergone prolonged submersion and require prolonged re￾suscitation,4,5 successful resuscitation with full neurologic recovery has occasionally occurred with prolonged submer￾sion in icy water.6–8 For this reason, scene resuscitation should be initiated and the victim transported to an ED unless there is obvious physical evidence of death. Modifications to Basic Life Support for Drowning No modification of standard BLS sequencing is necessary. Some cautions are appropriate, however, when beginning CPR for the drowning victim. Recovery From the Water When attempting to rescue a drowning victim, the rescuer should get to the victim as quickly as possible, preferably by some conveyance (boat, raft, surfboard, or flotation device). The rescuer must always be aware of personal safety. Recent evidence indicates that routine stabilization of the cervical spine is not necessary unless the circumstances leading to the submersion episode indicate that trauma is likely (Class IIa). These circumstances include a history of diving, use of a water slide, signs of injury, or signs of alcohol intoxication.9 In the absence of such indicators, spinal injury is unlikely. Manual cervical spine stabilization and spine immobilization equipment may impede adequate opening of the airway, and they compli￾cate and may delay the delivery of rescue breaths. Rescue Breathing The first and most important treatment of the drowning victim is the immediate provision of ventilation. Prompt initiation of rescue breathing increases the victim’s chance of survival.10 Rescue breathing is usually performed when the unresponsive victim is in shallow water or out of the water. If it is difficult for the rescuer to pinch the victim’s nose, support the head, and open the airway in the water, mouth￾to-nose ventilation may be used as an alternative to mouth￾to-mouth ventilation. Untrained rescuers should not try to provide care while the victim is still in deep water. Management of the drowning victim’s airway and breath￾ing is similar to that recommended for any victim of cardio￾pulmonary arrest. There is no need to clear the airway of aspirated water, because only a modest amount of water is aspirated by the majority of drowning victims and it is rapidly absorbed into the central circulation, so it does not act as an obstruction in the trachea.5,11 Some victims aspirate nothing because they develop laryngospasm or breath-holding.5,12 Attempts to remove water from the breathing passages by any means other than suction (eg, abdominal thrusts or the Heimlich maneuver) are unnecessary and potentially danger- (Circulation. 2005;112:IV-133-IV-135.) © 2005 American Heart Association. This special supplement to Circulation is freely available at http://www.circulationaha.org DOI: 10.1161/CIRCULATIONAHA.105.166565 IV-133

lV-134 Circulation December 13. 2005 ous. The routine use of abdominal thrusts or the Heimlich note that it may be effective for other causes of cardiac arrest maneuve or drowning victims is not recommended lowever, the effectiveness of induced hypothermia for drowning victims has not been established, and evaluation of Chest Compressions this approach is warranted. The 2002 World Congress on As soon as the unresponsive victim is removed from the Drowning recommended further studies to identify the best water, the rescuer should open the airway, check for breath- ing, and if there is no breathing, give 2 rescue breaths that treatments for drowning victims. make the chest rise (if this was not done in the water). After S umma ry delivery of 2 effective breaths, the lay rescuer should imme- Prevention measures can reduce the incidence of drowning ately begin chest compressions and provide cycles of and immediate, high-quality bystander CPR and early BLS compressions and ventilations. The healthcare provider care can improve survival. Rescue breathing should be should check for a central pulse. The pulse may be difficult to provided even before the victim is pulled from the water if appreciate in a drowning victim, particularly if the victim is possible. Routine stabilization of the cervical spine is not cold. If the healthcare provider does not definitely feel a pulse within 10 seconds, the healthcare provider should start cycles needed. Further studies are necessary to improve neurologic outcome for drowning victims. of compressions and ventilations. Only trained rescuers should try to provide chest compressions in the water References Once the victim is out of the water. if the victim is 1. Thompson DC. Rivara FP. Pool fencing for preventing drowning in unresponsive and not breathing(and the healthcare provider children. Cochrane Database Syst Rev. 2000: CDO01047 does not feel a pulse) after delivery of 2 rescue breaths. 2. Quan L, Kinder D. Pediatric submersions: prehospital predictors of rescuers should attach an AED and attempt defibrillation if a outcome. Pediatrics. 1992. 90: 909-913 3. Idris AH, Berg RA, Bierens J. Bossaert L, Branche CM, Gabrielli A, shockable rhythm is identified. If hypothermia is present, Part 10.4 Szpilman D. Wigginton JG. Modell JH. Recommended guidelines for niform reporting of data from drowning: the"Utstein style. Resusci- Vomiting by the victim During Resuscitation falton.2003:59:45-57 The victim may vomit when the rescuer performs chest 4. Quan L, Wentz KR, Gore E, Copass MK Outcome and predictors of ome in pediatric submersion victims receiving prehospital care in compressions or rescue breathing. In fact, in a 10-year study King County, Washington. Pediatrics. 1990: 86: 586-59 in Australia, two thirds of victims who received rescue 5. Modell JH, Davis JH EconO breathing and 86% of victims who required compressions and Anesthesiology. 1969: 30: 41 ventilations vomited. 13 If vomiting occurs. turn the victim's 6. Southwick FS, Dalglish PHJ. Recovery after prolonged asystolic cardiac ofound hypothermia: a case report and literature review. mouth to the side and remove the vomitus using your finger. JAMA.1980243:1250-1253 a cloth, or suction. If spinal cord injury is possible, logroll the 7. Siebke H. Rod T, Breivik H, Link B. Survival after 40 minutes: sub- victim so that the head. neck and torso are turned as a unit. mersion without cerebral sequelae. Lancet. 1975: 1: 1275-1277. 8. Bolte RG. Black PG. Bowers RS. Thorne JK. Corneli HM. The use of corporeal rewarming in a child submerged for 66 minutes. JAMA Modifications to ACLS for Drowning 1988:260:377-379 The drowning victim in cardiac arrest requires ACLS, includ- 9. Watson Rs, Cummings P, Quan L, Bratton S, Weiss NS. Cervical spine ing early intubation. Every drowning victim, even one who injuries among submersion victims. J Tranma. 2001: 51: 658-662 requires only minimal resuscitation before recovery, requires 10. Kyriacou DN, Arcinue EL, Peek C, Kraus JF. Effect of immediate resuscitation on children with submersion injury. Pediatrics. 1994: 9. monitored transport and evaluation at a medical facility Victims in cardiac arrest may present with asystole, pulse- Il. Rosen P, Stoto M, Harley J. The use of the Heimlich maneuver in less electrical activity, or pulseless ventricular car-drowning: Institute of Medicine report J Emerg Med. 1995 97-405 tachycardia/ventricular fibrillation (VF). Follow the guide- 12. Modell JH. Drowning. N Engl J Med. 1993: 328:253-256 lines for pediatric advanced life support and ACLS for 13. Manolios N, Mackie I. Drowning and near-drowning on Australian treatment of these rhythms. Case reports document the use of beaches patrolled by life-savers: a 10-year study, 1973-1983. Med J Aust surfactant for fresh water-induced respiratory distress, but 1988:148:165-167,170-171 further research is needed. 14-16 The use of extracorporeal 14. Onarheim H, Vik V. Porcine surfactant(Curosurf) for acute respiratory ailure after near-drowning in 12 year old. Acta Anaesthesiol Scand. membrane oxygenation in young children with severe hypo 2004:48:778-781 thermia after submersion is documented in case reports& 17 15. Staudinger T, Bankier A, Strohmaier w,Weiss K, Locker GI, Knapp S, There is insufficient evidence to support or refute the use of Roggla M, Laczika K, Frass M. Exogenous surfactant therapy in a patient barbiturates, steroids, 8 nitric oxide, 9 therapeutic hypother with adult respiratory distress syndrome after near drowning. Resusci- mia after ret f spontaneous circulation, 20 or 16. Suzuki H, Ohta T, Iwata K, Yamaguchi K, Sato T Surfactant therapy for 383-3ga y failure due to near-drowning. Eur J Pediatr. 1996: 155 Improving Neurologic Outcomes: 17. Thalmann M, Trampitsch E, Haberfeliner N, Eisendle E. KraschI R, Kobinia G Resuscitation in near drowning with extracorporeal membrane Therapeutic Hypothermia oxygenation. Ann Thorac Surg. 2001: 72: 607-608 Recent randomized controlled trials (LOE 1)22 and (LOE 2) 18.F gency medicine: best and subsequent consensus recommendations,25 support the BETs from the Manchester Royal Infirmary. Corticosteroids in the m use of therapeutic hypothermia in patients who remain in a 19. Takano Y. Hirosako s. Yamaguchi T, Saita N, Suga M, Kukita I coma after resuscitation from cardiac arrest caused by vF and Okamoto K, Ando M. [Nitric oxide inhalation as an effective therapy for

ous.11 The routine use of abdominal thrusts or the Heimlich maneuver for drowning victims is not recommended. Chest Compressions As soon as the unresponsive victim is removed from the water, the rescuer should open the airway, check for breath￾ing, and if there is no breathing, give 2 rescue breaths that make the chest rise (if this was not done in the water). After delivery of 2 effective breaths, the lay rescuer should imme￾diately begin chest compressions and provide cycles of compressions and ventilations. The healthcare provider should check for a central pulse. The pulse may be difficult to appreciate in a drowning victim, particularly if the victim is cold. If the healthcare provider does not definitely feel a pulse within 10 seconds, the healthcare provider should start cycles of compressions and ventilations. Only trained rescuers should try to provide chest compressions in the water. Once the victim is out of the water, if the victim is unresponsive and not breathing (and the healthcare provider does not feel a pulse) after delivery of 2 rescue breaths, rescuers should attach an AED and attempt defibrillation if a shockable rhythm is identified. If hypothermia is present, see Part 10.4. Vomiting by the Victim During Resuscitation The victim may vomit when the rescuer performs chest compressions or rescue breathing. In fact, in a 10-year study in Australia, two thirds of victims who received rescue breathing and 86% of victims who required compressions and ventilations vomited.13 If vomiting occurs, turn the victim’s mouth to the side and remove the vomitus using your finger, a cloth, or suction. If spinal cord injury is possible, logroll the victim so that the head, neck, and torso are turned as a unit. Modifications to ACLS for Drowning The drowning victim in cardiac arrest requires ACLS, includ￾ing early intubation. Every drowning victim, even one who requires only minimal resuscitation before recovery, requires monitored transport and evaluation at a medical facility. Victims in cardiac arrest may present with asystole, pulse￾less electrical activity, or pulseless ventricular tachycardia/ventricular fibrillation (VF). Follow the guide￾lines for pediatric advanced life support and ACLS for treatment of these rhythms. Case reports document the use of surfactant for fresh water–induced respiratory distress, but further research is needed.14 –16 The use of extracorporeal membrane oxygenation in young children with severe hypo￾thermia after submersion is documented in case reports.8,17 There is insufficient evidence to support or refute the use of barbiturates, steroids,18 nitric oxide,19 therapeutic hypother￾mia after return of spontaneous circulation,20 or vasopressin.21 Improving Neurologic Outcomes: Therapeutic Hypothermia Recent randomized controlled trials (LOE 1)22 and (LOE 2)23 and subsequent consensus recommendations24,25 support the use of therapeutic hypothermia in patients who remain in a coma after resuscitation from cardiac arrest caused by VF and note that it may be effective for other causes of cardiac arrest. However, the effectiveness of induced hypothermia for drowning victims has not been established, and evaluation of this approach is warranted. The 2002 World Congress on Drowning recommended further studies to identify the best treatments for drowning victims.3 Summary Prevention measures can reduce the incidence of drowning, and immediate, high-quality bystander CPR and early BLS care can improve survival. Rescue breathing should be provided even before the victim is pulled from the water if possible. Routine stabilization of the cervical spine is not needed. Further studies are necessary to improve neurologic outcome for drowning victims. References 1. Thompson DC, Rivara FP. Pool fencing for preventing drowning in children. Cochrane Database Syst Rev. 2000;CD001047. 2. Quan L, Kinder D. Pediatric submersions: prehospital predictors of outcome. Pediatrics. 1992;90:909 –913. 3. Idris AH, Berg RA, Bierens J, Bossaert L, Branche CM, Gabrielli A, Graves SA, Handley AJ, Hoelle R, Morley PT, Papa L, Pepe PE, Quan L, Szpilman D, Wigginton JG, Modell JH. Recommended guidelines for uniform reporting of data from drowning: the “Utstein style.” Resusci￾tation. 2003;59:45–57. 4. Quan L, Wentz KR, Gore EJ, Copass MK. Outcome and predictors of outcome in pediatric submersion victims receiving prehospital care in King County, Washington. Pediatrics. 1990;86:586 –593. 5. Modell JH, Davis JH. Electrolyte changes in human drowning victims. Anesthesiology. 1969;30:414 – 420. 6. Southwick FS, Dalglish PHJ. Recovery after prolonged asystolic cardiac arrest in profound hypothermia: a case report and literature review. JAMA. 1980;243:1250 –1253. 7. Siebke H, Rod T, Breivik H, Link B. Survival after 40 minutes: sub￾mersion without cerebral sequelae. Lancet. 1975;1:1275–1277. 8. Bolte RG, Black PG, Bowers RS, Thorne JK, Corneli HM. The use of extracorporeal rewarming in a child submerged for 66 minutes. JAMA. 1988;260:377–379. 9. Watson RS, Cummings P, Quan L, Bratton S, Weiss NS. Cervical spine injuries among submersion victims. J Trauma. 2001;51:658 – 662. 10. Kyriacou DN, Arcinue EL, Peek C, Kraus JF. Effect of immediate resuscitation on children with submersion injury. Pediatrics. 1994;94: 137–142. 11. Rosen P, Stoto M, Harley J. The use of the Heimlich maneuver in near-drowning: Institute of Medicine report. J Emerg Med. 1995;13: 397– 405. 12. Modell JH. Drowning. N Engl J Med. 1993;328:253–256. 13. Manolios N, Mackie I. Drowning and near-drowning on Australian beaches patrolled by life-savers: a 10-year study, 1973–1983. Med J Aust. 1988;148:165–167, 170 –171. 14. Onarheim H, Vik V. Porcine surfactant (Curosurf) for acute respiratory failure after near-drowning in 12 year old. Acta Anaesthesiol Scand. 2004;48:778 –781. 15. Staudinger T, Bankier A, Strohmaier W, Weiss K, Locker GJ, Knapp S, Roggla M, Laczika K, Frass M. Exogenous surfactant therapy in a patient with adult respiratory distress syndrome after near drowning. Resusci￾tation. 1997;35:179 –182. 16. Suzuki H, Ohta T, Iwata K, Yamaguchi K, Sato T. Surfactant therapy for respiratory failure due to near-drowning. Eur J Pediatr. 1996;155: 383–384. 17. Thalmann M, Trampitsch E, Haberfellner N, Eisendle E, Kraschl R, Kobinia G. Resuscitation in near drowning with extracorporeal membrane oxygenation. Ann Thorac Surg. 2001;72:607– 608. 18. Foex BA, Boyd R. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Corticosteroids in the man￾agement of near-drowning. Emerg Med J. 2001;18:465– 466. 19. Takano Y, Hirosako S, Yamaguchi T, Saita N, Suga M, Kukita I, Okamoto K, Ando M. [Nitric oxide inhalation as an effective therapy for IV-134 Circulation December 13, 2005

Part 10.3: Drowning /V-/35 acute respiratory distress syndrome due to near-drowning: a case report] 23. Bernard SA, Gray Tw. Buist MD, Jones BM, Silvester W, Gutteridge G, Nihon Kokyuki Gakkai Zasshi. 1999: 37: 997-1002 Smith K. Treatment of comatose survivors of out-of-hospital cardiac 20. Williamson JP, Illing R Gertler P, Braude S Near-drowning treated with induced hypothermia. N Engl J Med. 20 therapeutic hypothermia. Med J Aust. 2004; 181: 500-50 24. Nolan JP, Morley Pl, Vanden Hoek TL, Hickey RW. Therapeutic hypo- 21. Sumann G, Krismer AC, Wenzel V, Adelsmayr E, Schwarz B, Lindner thermia after cardiac arrest. An advisory statement by the Advanced life KH, Mair P. Cardiopulmonary ation after near drowning and Support Task Force of the International Liaison Committee on Resusci- hypothermia: restoration of spontaneous circulation after vasopressin. tation. Resuscitation. 2003: 57: 231-235 Acta Anaesthesiol Scand. 2003: 47: 363-365 25. Nolan JP, Morley PT, Vanden Hoek TL, Hickey Rw, Kloeck wG, Billi J, 22. Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypo- Bottiger BW, Okada K Reyes C, Shuster M, Steen PA, Weil MH, Wenzel V, Carli P. Atkins D. Therapeutic hypothemia after cardiac arrest: an advisory thermia to improve the neurologic outcome after cardiac arrest. N Engl statement by the Advanced Life Support Task Force of the Intermational Liaison Med.2002:346:549-556 Committee on Resuscitation. Circulation. 2003: 108: 118-121

acute respiratory distress syndrome due to near-drowning: a case report.] Nihon Kokyuki Gakkai Zasshi. 1999;37:997–1002. 20. Williamson JP, Illing R, Gertler P, Braude S. Near-drowning treated with therapeutic hypothermia. Med J Aust. 2004;181:500 –501. 21. Sumann G, Krismer AC, Wenzel V, Adelsmayr E, Schwarz B, Lindner KH, Mair P. Cardiopulmonary resuscitation after near drowning and hypothermia: restoration of spontaneous circulation after vasopressin. Acta Anaesthesiol Scand. 2003;47:363–365. 22. Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypo￾thermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549 –556. 23. Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557–563. 24. Nolan JP, Morley PT, Vanden Hoek TL, Hickey RW. Therapeutic hypo￾thermia after cardiac arrest. An advisory statement by the Advanced Life Support Task Force of the International Liaison Committee on Resusci￾tation. Resuscitation. 2003;57:231–235. 25. Nolan JP, Morley PT, Vanden Hoek TL, Hickey RW, Kloeck WG, Billi J, Bottiger BW, Okada K, Reyes C, Shuster M, Steen PA, Weil MH, Wenzel V, Carli P, Atkins D. Therapeutic hypothermia after cardiac arrest: an advisory statement by the Advanced Life Support Task Force of the International Liaison Committee on Resuscitation. Circulation. 2003;108:118–121. Part 10.3: Drowning IV-135