Diseases of the cardiovascular system Malign Department of Pathology and Pathophysiology School of Medicine, Zhejiang University 3
Diseases of the cardiovascular system Maliqin Department of Pathology and Pathophysiology School of Medicine, Zhejiang University
atherosclerosIs(AS 1. etiology and pathogenesis Risk factors 6o Hyperlipemia: increased LDL, TG, VLDL, apoB, Lp(a) decreased HDL, apoA-l Hypertension %s Cigarette smoking &o Elevated blood sugar levels ☆ The other factors
atherosclerosis(AS) 1. etiology and pathogenesis Risk factors ❖ Hyperlipemia:increased LDL, TG, VLDL, apoB,Lp(a) decreased HDL,apoA-I ❖ Hypertension ❖ Cigarette smoking ❖ Elevated blood sugar levels ❖ The other factors
pathogenesis Theory of inflammatory response to Injury . The injury of the endothelium s The accumulation of lipid The infiltration of macrophages %o The proliferation of SMc
pathogenesis --Theory of inflammatory response to injury ❖The injury of the endothelium ❖The accumulation of lipid ❖The infiltration of macrophages ❖The proliferation of SMC
2. morphology Predilection for large arteries and medium-sized arteries Basic lesion o Fatty streak Accumulated lipid, foam cell o Fibrous plaque- Fibrous cap
2.morphology Predilection for large arteries and medium-sized arteries Basic lesion ❖Fatty streak Accumulated lipid, foam cell ❖Fibrous plaque-- Fibrous cap
黄色脂 质条纹 5 c Fig 3. 1. Lipidosis of the aorta. W
黄色脂 质条纹
2. morphology Predilection for large arteries and medium-sized arteries Basic lesion 冷 Fatty streak Accumulated lipid, foam cell Fibrous plaque- Fibrous cap
2.morphology Predilection for large arteries and medium-sized arteries Basic lesion ❖Fatty streak Accumulated lipid, foam cell ❖Fibrous plaque-- Fibrous cap
正常主动脉 动脉粥样硬化的纤维斑块病变 ( Fig 3-5. Normal and arteriosclerotic aorta
正常主动脉 动脉粥样硬化的纤维斑块病变
动脉管壁一侧明显增厚
动脉管壁一侧明显增厚
Atheromatous plaque ( atheroma) Fibrous cap cholesterol crystal necrotic debris foam cell calcification neovascular formation
•Atheromatous plaque (atheroma) Fibrous cap cholesterol crystal necnotic debris foam cell calcification neovascular formation
atheroma H 1 cm- Fig3.2. Atheroma of the aorta
atheroma