定义:当具有生长功能的子宫内膜组织出现在子宫腔被覆粘膜以外的身体其他部位 时,称子宫内膜异位症简称内异症。良性疾病具有恶性生物学行为:高度的 复发性和浸润性。 发病情况:一般仅见于育龄女性(25~45岁) 发病率:3~10%

概述 先天性甲状腺功能减低症是一种常 见的小儿内分泌疾病,是由于先天因素 ,使甲状腺激素合成不足,导致小儿代 谢低下、生长发育迟缓、智力发育障碍 。小儿出生前后发病可致中枢神经系统 不可逆损害,终身智力低下

万古霉素是由 Micormick等于1956年从一株东 方拟无枝酸菌的发酵液中分离得到的一种糖肽 类抗生素。万古霉素问世后的前20年,由于青 霉素和头孢菌素类抗生素的上市使用,万古霉 素仅作为保留药物,治疗由少数金黄色葡萄球 菌引起的严重感染性疾病,临床使用很少

帕金森氏病:慢性进行性运动障碍,属锥体外系疾病。多老年 人发病。1817年,首次报道。1953年,肯定病变部位在黑质和 纹状体。1960年,发现与黑质纹状体中DA含量显著降低

静脉输液是将大量无菌溶液或药物直接滴入静脉的技术。 一、输液目的 1.补充水和电解质,以调节或维持人体内水、电解质及酸碱的平衡。 2.纠正血容量不足,维持血压和改善微循环的灌注量。 3.解毒、控制感染和治疗疾病

DISCOVERy OF THE ROLE OF UBIQUITIN IN PROTEIN DEGRADATION HISTORICAL FACTS Courtesy of Sam Griffiths-Jones. Used with permission Source: \Peptide models for protein beta-sheets hD thesis, University of Nottingham, 2001 8(1975)Ubiquitin was first isolated by Gideon Goldstein and colleagues from the thymus(reason why it was originally thought to be a thymic hormone)

Images removed due to copyright considerations See Fig. 2 in David J. Katzmann, Greg Odorizzi Scott D. Emr RECEPTOR DOWNREGULATION AND MULTIVESICULAR-BODY SORTING Nature Reviews Molecular Cell Biology 3, 893-905(2002); doi: 10.1038/nrm973 See Fig. 7 in: Katzmann DJ, Stefan CJ, Babst M, Emr SD

How p53 and Rb pathway function may be disrupted in cancer cells Components of the pathway which are found altered in human cancers are shown in red on the diagram above p53 and Rb themselves may be inactivated by gene mutation (loss of both copies or also as in familial retinoblastoma and Li-Fraumeni syndrome where there are inherited mutations in one copy of Rb or p53 gene respectively. Alternatively

Epstein-Barr virus (EBV), is the herpesvirus that causes infectious mononucleosis and is associated with a number of cancers, particularly lymphomas in immunosuppressed persons including persons with AIDS EBV is a ubiquitous virus, so common that it has been difficult to determine whether it is the cause of certain diseases or whether it is simply there as an artifact

PROTACS: CHIMERIC MOLECULES TO TARGET PROTEINS FOR UBIQUITINATION AND (taken from KM Sakamoto, Mol. Genetics and Metabolism 77(2002)44-56) target targettargettarget target target target target target To circumvent the problem of transducing cells at