Section C CELL DEATH
CELL DEATH
Common type of necrosis after exogenous stimuli。 Swelling, denaturation and coagulation of proteins Breakdown of cellular organelles Cell rupture
• Swelling, denaturation and coagulation of proteins • Breakdown of cellular organelles • Cell rupture Common type of necrosis after exogenous stimuli
NECROSIS The sum of the morphologic changes that follow cell death in living tissue and organ Denaturation of proteins. Enzymatic digestion of organelles and cytosol
NECROSIS The sum of the morphologic changes that follow cell death in living tissue and organ: • Denaturation of proteins. • Enzymatic digestion of organelles and cytosol
AUTOLYSIS Enzymatic digestion by lysosomal enzymes of the dead cells themselves HETEROLYSIS Digestion by lysosomal enzymes of immigrant leukocytes
•Enzymatic digestion by lysosomal enzymes of the dead cells themselves. AUTOLYSIS HETEROLYSIS • Digestion by lysosomal enzymes of immigrant leukocytes
Three pattern of nuclear changes Karyolysis(DNase activity) Pyknosis ( dna condensation) Karyorrhexis(fragmentation of pyknotic nucleus)
Three pattern of nuclear changes Karyolysis (DNase activity) Pyknosis (DNA condensation) Karyorrhexis (fragmentation of pyknotic nucleus)
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Morphologic appearance of necrosis Increased eosinopl philia Loss of rna in the cytoplasm Increased binding of eosin to denatured cytoplasmic protein More glassy homogeneous appearance Loss of glycogen particles Vacuolated and moth-eaten cytoplasm Calcification of necrotic cells
Morphologic appearance of necrosis • Increased eosinophilia: Loss of RNA in the cytoplasm Increased binding of eosin to denatured cytoplasmic protein • More glassy homogeneous appearance Loss of glycogen particles • Vacuolated and moth-eaten cytoplasm • Calcification of necrotic cells
TYPES OF CELL DEATH necrosis Coagulation necrosis Caseous necrosis Gangrene Liquefaction necrosis( fat necrosis) fibrinoid necrosis Apoptosis
TYPES OF CELL DEATH • necrosis Coagulation necrosis Caseous necrosis Gangrene Liquefaction necrosis( fat necrosis) Fibrinoid necrosis • Apoptosis
Coagulation necrosis Denatures of both structural and enzymatic proteins by injury or the subsequent increasing intracellular acidosis
Coagulation necrosis Denatures of both structural and enzymatic proteins by injury or the subsequent increasing intracellular acidosis
肾凝固性坏死